By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating in Albuquerque, New Mexico, by NewsRx journalists, research stated, "Field cancerization denotes the occurrence of molecular alterations in histologically normal tissues adjacent to tumors. In prostate cancer, identification of field cancerization has several potential clinical applications."
The news reporters obtained a quote from the research from the University of New Mexico Health Sciences Center, "However, prostate field cancerization remains ill defined. Our previous work has shown up-regulated mRNA of the transcription factor early growth response 1 (EGR-1) and the lipogenic enzyme fatty acid synthase (FAS) in tissues adjacent to prostate cancer. Immunofluorescence data were analyzed quantitatively by spectral imaging and linear unmixing to determine the protein expression levels of EGR-1 and FAS in human cancerous, histologically normal adjacent, and disease-free prostate tissues. EGR-1 expression was elevated in both structurally intact tumor adjacent (1.6 x on average) and in tumor (3.0 x on average) tissues compared to disease-free tissues. In addition, the ratio of cytoplasmic versus nuclear EGR-1 expression was elevated in both tumor adjacent and tumor tissues. Similarly, FAS expression was elevated in both tumor adjacent (2.7 x on average) and in tumor (2.5 x on average) compared to disease-free tissues. EGR-1 and FAS expression is similarly deregulated in tumor and structurally intact adjacent prostate tissues and defines field cancerization. In cases with high suspicion of prostate cancer but negative biopsy, identification of field cancerization could help clinicians target areas for repeat biopsy. Field cancerization at surgical margins on prostatectomy specimen should also be looked at as a predictor of cancer recurrence."
According to the news reporters, the research concluded: "EGR-1 and FAS could also serve as molecular targets for chemoprevention."
For more information on this research see: Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization. The Prostate, 2012;72(11):1159-70 (see also technology.html">Biotechnology).
Our news correspondents report that additional information may be obtained by contacting A.C. Jones, Dept. of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States. Additional authors for this research include K.A. Trujillo, G.K. Phillips, T.M. Fleet, J.K. Murton, V. Severns, S.K. Shah, M.S. Davis, A.Y. Smith, J.K. Griffith, E.G. Fischer and M. Bisoffi.
Keywords for this news article include: Biotechnology, Biopsy, Surgery, Oncology, Synthase, New Mexico, Albuquerque, United States, Prostate Cancer, Cancer Gene Therapy, Prostatic Neoplasms, Enzymes and Coenzymes, North and Central America, Operative Surgical Procedures.
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