By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Ultrasound is now available. According to news originating from Lecce, Italy, by NewsRx correspondents, research stated, "Nanosized particles are receiving increasing attention as future contrast agents (CAs) for ultrasound (US) molecular imaging, possibly decorated on its surface with biological recognition agents for targeted delivery and deposition of therapeutics. In particular, silica nanospheres (SiNSs) have been demonstrated to be feasible in terms of contrast enhancement on conventional US systems."
Our news journalists obtained a quote from the research from National Research Council, "In this work, we evaluated the cytotoxicity of SiNSs on breast cancer (MCF-7) and HeLa (cervical cancer) cells employing NSs with sizes ranging from 160 to 330 nm and concentration range of 1.5-5 mg/mL. Cell viability was evaluated in terms of size, dose and time dependence, performing the MTT reduction assay with coated and uncoated SiNSs. Whereas uncoated SiNSs caused a variable significant decrease in cell viability on both cell lines mainly depending on size and exposure time, PEGylated SiNSs (SiNSs-PEG) exhibit a high level of biocompatibility. In fact, after 72-h incubation, viability of both cell types was above the cutoff value of 70 % at concentration up to 5 mg/mL. We also investigated the acoustical behavior of coated and uncoated SiNSs within conventional diagnostic US fields in order to determine a suitable configuration, in terms of particle size and concentration, for their employment as targetable CAs."
According to the news editors, the research concluded: "Our results indicate that the employment of SiNSs with diameters around 240 nm assures the most effective contrast enhancement even at the lowest tested concentration, coupled with the possibility of targeting all tumor tissues, being the SiNSs still in a size range where reticuloendothelial system trapping effect is relatively low."
For more information on this research see: Epithelial cell biocompatibility of silica nanospheres for contrast-enhanced ultrasound molecular imaging. Journal of Nanoparticle Research, 2013;15(7):291-303. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
The news correspondents report that additional information may be obtained from F. Chiriaco, CNR, IFC, I-73100 Lecce, Italy. Additional authors for this research include F. Conversano, G. Soloperto, E. Casciaro, A. Ragusa, E.A. Sbenaglia, L. Dipaola and S. Casciaro (see also Ultrasound).
Keywords for this news article include: Lecce, Italy, Europe, Nanophere, Nanosphere, Ultrasound, Nanotechnology, Epithelial Cells, Molecular Imaging, Emerging Technologies
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