By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Cell Biology is the subject of a report. According to news reporting from London, United Kingdom, by NewsRx journalists, research stated, "Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a broad range of traits."
The news correspondents obtained a quote from the research from King's College, "We found that hitherto unpublished genes were as likely to reveal phenotypes as known genes, suggesting that novel genes represent a rich resource for investigating the molecular basis of disease. We found many unexpected phenotypes detected only because we screened for them, emphasizing the value of screening all mutants for a wide range of traits. Haploinsufficiency and pleiotropy were both surprisingly common. Forty-two percent of genes were essential for viability, and these were less likely to have a paralog and more likely to contribute to a protein complex than other genes."
According to the news reporters, the research concluded: "Phenotypic data and more than 900 mutants are openly available for further analysis."
For more information on this research see: Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes. Cell, 2013;154(2):452-464. Cell can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Cell - www.elsevier.com/wps/product/cws_home/621181)
Our news journalists report that additional information may be obtained by contacting J.K. White, Kings Coll London, Wolfson Center Age Related Dis, London SE1 1UL, United Kingdom. Additional authors for this research include A.K. Gerdin, N.A. Karp, E. Ryder, M. Buljan, J.N. Bussell, J. Salisbury, S. Clare, N.J. Ingham, C. Podrini, R. Houghton, J. Estabel, J.R. Bottomley, D.G. Melvin, D. Sunter, N.C. Adams, D. Tannahill, D.W. Logan and D. MacArthur (see also Cell Biology).
Keywords for this news article include: London, Europe, Cell Biology, United Kingdom
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