By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Caenorhabditis elegans are discussed in a new report. According to news reporting originating in Durham, North Carolina, by NewsRx journalists, research stated, "Engineered cerium oxide nanoparticles (CeO2 NPs) are widely used in biomedical and engineering manufacturing industries. Previous research has shown the ability of CeO2 NPs to act as a redox catalyst, suggesting potential to both induce and alleviate oxidative stress in organisms."
The news reporters obtained a quote from the research from Duke University, "In this study, Caenorhabditis elegans and zebrafish (Danio rerio) were dosed with commercially available CeO2 NPs. Non-nano cerium oxide powder (CeO2) was used as a positive control for cerium toxicity. CeO2 NPs suspended in standard United States Environmental Protection Agency reconstituted moderately hard water, used to culture the C. elegans, quickly formed large polydisperse aggregates. Dosing solutions were renewed daily for 3 days. Exposure of wild-type nematodes resulted in dose-dependent growth inhibition detected for all 3 days (p < 0.0001). Non-nano CeO2 also caused significant growth inhibition (p < 0.0001), but the scale of inhibition was less at equivalent mass exposures compared with CeO2 NP exposure. Some metal and oxidative stress-sensitive mutant nematode strains showed mildly altered growth relative to the wild-type when dosed with 5 mg/L CeO2 NPs on days 2 and 3, thus providing weak evidence for a role for oxidative stress or metal sensitivity in CeO2 NP toxicity. Zebrafish microinjected with CeO2 NPs or CeO2 did not exhibit increased gross developmental defects compared with controls. Hyperspectral imaging showed that CeO2 NPs were ingested but not detectable inside the cells of C. elegans."
According to the news reporters, the research concluded: "Growth inhibition observed in C. elegans may be explained at least in part by a non-specific inhibition of feeding caused by CeO2 NPs aggregating around bacterial food and/or inside the gut tract."
For more information on this research see: Cerium Oxide Nanoparticles are More Toxic than Equimolar Bulk Cerium Oxide in Caenorhabditis elegans. Archives of Environmental Contamination and Toxicology, 2013;65(2):224-233. Archives of Environmental Contamination and Toxicology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Archives of Environmental Contamination and Toxicology - www.springerlink.com/content/0090-4341/)
Our news correspondents report that additional information may be obtained by contacting M.C. Arnold, Duke University, Pratt Sch Engn, Durham, NC 27708, United States. Additional authors for this research include A.R. Badireddy, M.R. Wiesner, R.T. Di Giulio and J.N. Meyer (see also Caenorhabditis elegans).
Keywords for this news article include: Durham, Rhabditidae, Nanoparticle, United States, Life Sciences, North Carolina, Nanotechnology, Emerging Technologies, Caenorhabditis elegans, North and Central America
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