By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Gram-Positive Bacteria are presented in a new report. According to news reporting from Gujarat, India, by NewsRx journalists, research stated, "The present work reports a series of novel cationic fullerene derivatives bearing a substituted-quinazolinone moiety as a side arm. Fullerene-quinazolinone conjugates synthesized using the 1,3-dipolar cycloaddition reaction of C-60 with azomethine ylides generated from the corresponding Schiff bases of substituted quinazolinone were characterized by elemental analysis, FT-IR, H-1 NMR, C-13 NMR and ESI-MS and screened for their antibacterial activity against Mycobacterium tuberculosis (H (37) Rv strain)."
The news correspondents obtained a quote from the research from the School of Science, "All the compounds exhibited significant activity with the most effective having MIC in the range of 1.562-3.125 mu g/mL. Compound 9f exhibited good biological activity compared to standard drugs. We developed a computational strategy based on the modeled M. tuberculosis hypoxanthine-guanine phosphoribosyltransferase (HGPRT) using homology modeling techniques and studied its binding pattern with synthesized fullerene derivatives."
According to the news reporters, the research concluded: "We then explored the surface geometry of the protein to place the cage adjacent to the active site while optimizing its quinazolinone side arm to establish H bonding with active site residues."
For more information on this research see: Synthesis and biological evaluation of cationic fullerene quinazolinone conjugates and their binding mode with modeled Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase enzyme. Journal of Molecular Modeling, 2013;19(8):3201-3217. Journal of Molecular Modeling can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Molecular Modeling - www.springerlink.com/content/1610-2940/)
Our news journalists report that additional information may be obtained by contacting M.B. Patel, Univ Sch Sci, ABC, Dept. of Bioinformat, Ahmadabad 380009, Gujarat, India. Additional authors for this research include S.P. Kumar, N.N. Valand, Y.T. Jasrai and S.K. Menon (see also Gram-Positive Bacteria).
Keywords for this news article include: Asia, India, Carbon, Gujarat, Fullerenes, Actinobacteria, Nanotechnology, Actinomycetales, Mycobacteriaceae, Gram-Positive Rods, Emerging Technologies, Gram-Positive Bacteria, Mycobacterium tuberculosis, Gram-Positive Asporogenous Rods
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