By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Biomaterials have been presented. According to news reporting originating in Gyeonggi Do, South Korea, by NewsRx journalists, research stated, "Coordination polymer gels have been recognized as promising hybrid nanoplatforms for imaging and therapeutic applications. Here we report functional metal-organic coordinated nanogels (GdNGs) for in vivo tumor imaging, whose non-crystalline and elastic nature allows for long blood circulation, as opposed to the rapid systemic clearance of common nanohybrids with rigid/crystalline frameworks."
The news reporters obtained a quote from the research from National Cancer Center, "The deformable structure of GdNGs was constructed by random crosslinking of highly flexible poly-ethyleneimines (PEI) with gadolinium (Gd3+) coordination. The in vitro characterization revealed that GdNGs have elasticity with an apparent Young's modulus of 3.0 MPa as well as minimal cytotoxicity owing to the tight chelation of Gd3+ ions. In contrast to common T-1-enhancing gadolinium complexes, GdNGs showed the capability of enhancing negative T-2 contrast (r(2) = 82.6 mm(-1) s(-1)) due to the Gd3+- concentrated nanostructure. Systemic administration of fluorescently labeled GdNGs with core and overall hydrodynamic sizes of similar to 65 and similar to 160 nm manifested efficient targeting and dual-modality (magnetic resonance/fluorescence) imaging of tumor in a mouse model. The minimal filtration by the reticuloendothelial system (RES) suggests that the structural deformability helps the large colloids circulate in the blood stream for tumor accumulation."
According to the news reporters, the research concluded: "The unusual performance of a large Gd3+-complexed colloid (minimal RES sequestration and high T-2 contrast enhancement) represents the versatile nature of nanoscopic organic-inorganic hybridization for biomedical applications."
For more information on this research see: Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging. Biomaterials, 2013;34(28):6846-6852. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting C.K. Lim, Natl Canc Center, Mol Imaging & Therapy Branch, Goyang Si 410769, Gyeonggi Do, South Korea. Additional authors for this research include A. Singh, J. Heo, D. Kim, K.E. Lee, H. Jeon, J. Koh, I.C. Kwon and S. Kim (see also Biomaterials).
Keywords for this news article include: Asia, Gadolinium, Gyeonggi Do, South Korea, Biomaterials, Lanthanoid Series Elements
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