By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Bone Research is the subject of a report. According to news reporting out of Montreal, Canada, by NewsRx editors, research stated, "Pyrophosphate ions are both inhibitors of HA formation and substrates for phosphatase enzymes. Unlike polyphosphates their hydrolysis results simultaneously in the complete loss of mineral formation inhibition and a localised elevation in orthophosphate ion concentration."
Our news journalists obtained a quote from the research from McGill University, "Despite recent advances in our knowledge of the role of the pyrophosphate ion, very little is known about the effects of pyrophosphate on bone formation and even less is known about its local delivery. In this work we first developed a self setting pyrophosphate based calcium cement system with appropriate handling properties and then compared its in vivo degradation properties with those of a non-pyrophosphate containing control. Contrary to expectation, the presence of the pyrophosphate phase in the cement matrix did not inhibit mineralisation of the healing bone around the implant, but actually appeared to stimulate it. In vitro evidence suggested that enzymatic action accelerated dissolution of the inorganic pyrophosphate ions, causing a simultaneous loss of their mineralisation inhibition and a localised rise in supersaturation with respect to HA. This is thought to be a rare example of a biologically responsive inorganic material and these materials seem to be worthy of further investigation."
According to the news editors, the research concluded: "Bioceramics to date have mainly been limited to orthophosphate, silicate and carbonate salts of calcium, here we report the successful application of a pyrophosphate material as a degradable osteoconductive bone repair cement."
For more information on this research see: The effect of amorphous pyrophosphate on calcium phosphate cement resorption and bone generation. Biomaterials, 2013;34(28):6631-6637. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting L.M. Grover, McGill University, Fac Dental, Dept. of Surg, Fac Med, Montreal, PQ H3A 2B2, Canada. Additional authors for this research include A.J. Wright, U. Gbureck, A. Bolarinwa, J.F. Song, Y. Liu, D.F. Farrar, G. Howling, J. Rose and J.E. Barralet (see also Bone Research).
Keywords for this news article include: Quebec, Canada, Anions, Montreal, Bone Research, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds, North and Central America
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