By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Bone Research is the subject of a report. According to news originating from Berlin, Germany, by NewsRx correspondents, research stated, "In biological tissues such as bone, cell function and activity crucially depend on the physical properties of the extracellular matrix which the cells synthesize and condition. During bone formation and remodeling, osteoblasts get embedded into the matrix they deposit and differentiate to osteocytes."
Our news journalists obtained a quote from the research from the Charite University Hospital and School of Medicine, "These cells form a dense network throughout the entire bone material. Osteocytes are known to orchestrate bone remodeling. However, the precise role of osteocytes during mineral homeostasis and their potential influence on bone material quality remains unclear. To understand the mutual influence of osteocytes and extracellular matrix, it is crucial to reveal their network organization in relation to the properties of their surrounding material. Here we visualize and topologically quantify the osteocyte network in mineralized bone sections with confocal laser scanning microscopy. At the same region of the sample, synchrotron small-angle X-ray scattering is used to determine nanoscopic bone mineral particle size and arrangement relative to the cell network. Major findings are that most of the mineral particles reside within less than a micrometer from the nearest cell network channel and that mineral particle characteristics depend on the distance from the cell network. The architecture of the network reveals optimization with respect to transport costs between cells and to blood vessels."
According to the news editors, the research concluded: "These findings quantitatively show that the osteocyte network provides access to a huge mineral reservoir in bone due to its dense organization. The observed correlation between the architecture of osteocyte networks and bone material properties supports the hypothesis that osteocytes interact with their mineralized vicinity and thus, participate in bone mineral homeostasis."
For more information on this research see: Architecture of the osteocyte network correlates with bone material quality. Journal of Bone and Mineral Research, 2013;28(8):1837-1845. Journal of Bone and Mineral Research can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Bone and Mineral Research - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1523-4681)
The news correspondents report that additional information may be obtained from M. Kerschnitzki, Charite, Center Musculoskeletal Surg, Berlin, Germany. Additional authors for this research include P. Kollmannsberger, M. Burghammer, G.N. Duda, R. Weinkamer, W. Wagermaier and P. Fratzl (see also Bone Research).
Keywords for this news article include: Berlin, Europe, Germany, Osteocytes, Osteoblasts, Bone Research
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