The assignee for this patent application, patent application serial number 858629, is
Reporters obtained the following quote from the background information supplied by the inventors: "Microvesicles are shed by eukaryotic cells, or budded off of the plasma membrane, to the exterior of the cell. These membrane vesicles are heterogeneous in size with diameters ranging from about 10 nm to about 5000 nm. The small microvesicles (approximately 10 to 1000 nm, and more often 30 to 200 nm in diameter) that are released by exocytosis of intracellular multivesicular bodies are sometimes referred to in the art as 'microvesicles.' Microvesicles contain nucleic acids that have been used as biomarkers for medical diagnosis, prognosis and therapy evaluation.
"There exists a need to further investigate the characteristics of microvesicles and to exploit the capabilities of these microvesicles in a variety of therapeutic and prophylactic indications."
In addition to obtaining background information on this patent application, NewsRx editors also obtained the inventors' summary information for this patent application: "The purified populations, compositions and methods of the invention use naturally secreted microvesicles to encapsulate, coat or otherwise associate with a viral vector particle to produce a microvesicle-associated vector, referred to herein as 'MAV'. For example, the viral particle can be encapsulated within a microvesicle, the viral particle can be associated with the microvesicle lipid membrane, the viral vector can be associated with one or more types of membrane-bound proteins or receptors on the microvesicle surface and/or interior, or any combination of these associations can be used to produce a MAV. The association between the microvesicle and the viral particle can be a covalent interaction or a non-covalent interaction.
"The association between the microvesicle and the viral particle protects or otherwise shields the viral particle. For example, the microvesicle shields the viral particle from an anti-virus immune response in vivo. The association between the microvesicle and the viral particle prevents or otherwise impedes the ability of neutralizing antibodies and/or complement components in a subject to bind or otherwise interact with the viral particle. Depending on the microvesicle type, the microvesicle components, including, for example, cytokines, cell surface receptors, may abrogate cytotoxic immunity against vector transduced cells types.
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