By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Data detailed on Biomedicine and Biomedical Engineering have been presented. According to news reporting out of Kyoto, Japan, by NewsRx editors, research stated, "Nicotine, one of the major pharmacologically active agents of cigarette smoke, has various effects on cell proliferation, and it has recently been reported to have angiogenic effects. In our previous study, we showed that the topical administration of nicotine at a low concentration accelerated wound healing."
Our news journalists obtained a quote from the research from Kyoto University, "This study aimed to evaluate the efficacy of nicotine and synergistic effects of combination treatment with nicotine and basic fibroblast growth factor (bFGF) in a murine excisional wound model treated with artificial dermis. Full-thickness defects (8 mm in diameter) were created on the backs of mice, and artificial dermis was sutured to the defects. Phosphate-buffered saline (10 ?L), nicotine (10(-3), 10(-4), or 10(-5) M), bFGF (0.5 ?g), and both bFGF and 10(-4) M nicotine were topically administered to the artificial dermal tissue for 7 d. The mice were killed on day 14, and the wound area, neoepithelium length, and area of newly formed capillaries in the artificial dermis were evaluated. The wound areas treated with 10(-4) M nicotine, bFGF, or bFGF plus 10(-4) M nicotine were significantly smaller than those in the control group. In these three groups, the neoepithelium in the bFGF plus 10(-4) M nicotine group was significantly longer than that in the other groups. There was no significant difference between the neoepithelium lengths of the control and 10(-5) M nicotine groups. The 10(-3) M nicotine group displayed the least re-epithelization among the groups."
According to the news editors, the research concluded: "In this study, 10(-4) M nicotine induced angiogenesis in, and accelerated the healing of, wounds treated with artificial dermis. bFGF and nicotine had synergistic effects, and the combined use of nicotine and bFGF is an effective wound healing method."
For more information on this research see: Treating a collagen scaffold with a low concentration of nicotine promoted angiogenesis and wound healing. Journal of Surgical Research, 2013;182(2):353-61. (Elsevier - www.elsevier.com; Journal of Surgical Research - www.elsevier.com/wps/product/cws_home/622901)
Our news journalists report that additional information may be obtained by contacting P.H. Liem, Dept. of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Additional authors for this research include N. Morimoto, R. Ito, K. Kawai and S. Suzuki (see also Biomedicine and Biomedical Engineering).
Keywords for this news article include: Asia, Tissue Engineering, Biomedicine and Biomedical Engineering, Kyoto, Japan, Collagen, Angiogenesis, Bioengineering, Extracellular Matrix Proteins.
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