By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteobacteria are discussed in a new report. According to news reporting originating from Bucharest, Romania, by NewsRx correspondents, research stated, "A new water-dispersible nanostructure based on magnetite (Fe3O4) and usnic acid (UA) was prepared in a well-shaped spherical form by a precipitation method. Nanoparticles were well individualized and homogeneous in size."
Our news editors obtained a quote from the research from the Institute of Atomic Physics, "The presence of Fe3O4@UA was confirmed by transmission electron microscopy, Fourier transform-infrared spectroscopy, and X-ray diffraction. The UA was entrapped in the magnetic nanoparticles during preparation and the amount of entrapped UA was estimated by thermogravimetric analysis. Fabricated nanostructures were tested on planktonic cells growth (minimal inhibitory concentration assay) and biofilm development on Gram-positive Staphylococcus aureus (S. aureus), Enterococcus faecalis (E. faecalis) and Gram-negative Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) reference strains. Concerning the influence of Fe3O4@UA on the planktonic bacterial cells, the functionalized magnetic nanoparticles exhibited a significantly improved antimicrobial activity against E. faecalis and E. coli, as comparedwith the Fe3O4 control. The UA incorporated into the magnetic nanoparticles exhibited a very significant inhibitory effect on the biofilm formed by the S. aureus and E. faecalis, on a wide range of concentrations, while in case of the-Gramnegative microbial strains, theUA-loaded nanoparticles inhibited the E. coli biofilm development, only at high concentrations, while for P. aeruginosa biofilms, no inhibitory effect was observed."
According to the news editors, the research concluded: "The obtained results demonstrate that the new water-dispersible Fe3O4@UA nanosystem, combining the advantages of the intrinsic antimicrobial features of the UA with the higher surface to volume ratio provided by the magnetic nanocarrier dispersible in water, exhibits efficient antimicrobial activity against planktonic and adherent cells, especially on Gram-positive strains."
For more information on this research see: In vitro activity of the new water-dispersible Fe3O4@usnic acid nanostructure against planktonic and sessile bacterial cells. Journal of Nanoparticle Research, 2013;15(7):151-160. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
The news editors report that additional information may be obtained by contacting A.M. Grumezescu, Natl Inst Lasers Plasma & Radiat Phys, Inst Atom Phys, Laser Surface Plasma Interact Lab, Lasers Department, Bucharest 77125, Romania. Additional authors for this research include A.I. Cotar, E. Andronescu, A. Ficai, C.D. Ghitulica, V. Grumezescu, B.S. Vasile and M.C. Chifiriuc (see also Proteobacteria).
Keywords for this news article include: Europe, Romania, Bucharest, Escherichia, Nanotechnology, Enterobacteriaceae, Gammaproteobacteria, Emerging Technologies, Magnetic Nanoparticles
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