"I am thrilled to receive this prestigious recognition. It gives me and my research team an extra boost of motivation to pursue innovative technologies for improving human healthcare," said Zhang.
"We approached this problem from an engineering point of view and bypassed all of this fundamental biology," said Zhang. "If the red blood cell has such a feature and we know that it has something to do with the membrane -- although we don't fully understand exactly what is going on at the protein level -- we just take the whole membrane. You put the cloak on the nanoparticle, and the nanoparticle looks like a red blood cell."
Zhang demonstrated in 2011 that a biodegradable polymer nanoparticle stuffed with a cocktail of small molecule drugs, and cloaked with a red blood cell membrane, could circulate in the bodies of mice for nearly two days. The research, which could enable cancer treatment that directly targets cancer cells, was published in the Proceedings of the
More recently, the team used the same cloaking method to demonstrate a nanosponge capable of safely removing a broad class of dangerous toxins from the bloodstream - including toxins produced by MRSA, E. coli, poisonous snakes and bees. Reported
In an announcement,
"Over the years, we've had success in choosing women and men whose innovations and companies have been profoundly influential on the direction of human affairs," says editor in chief and publisher
This year's honorees will be featured online at technologyreview.com">technologyreview.com, and in the September/October print magazine, which hits newsstands worldwide
UC San Diego engineers are no strangers to the
1999 Lawrence Saul, computer science professor
1999 Natalie Jeremijenko,
2003 Sangeeta Bhatia, then a bioengineering professor
2003 Christophe Schilling, former bioengineering graduate student
2004 Serge Belongie, computer science professor
2005 Trey Ideker, bioengineering professor
2006 Sumeet Singh, former computer science graduate
2007 Yoshi Kohno, former computer science graduate.
2011 Gert Lanckriet, professor of electrical and computer engineering
TNS 30TagarumaMar-130822-4463476 30TagarumaMar
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