By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Biotechnology. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Data have increasingly shown that interlukin-24 (IL-24) has growth suppression activity and can induce apoptosis in a broad spectrum of tumor cells. However, the therapeutic effect of IL-24 on human neuroblastoma has rarely been explored."
The news correspondents obtained a quote from the research from Xuzhou Medical College, "In this study, we used a human neuroblastoma cell line (SH-SY5Y) to reveal the effect of adenovirus-mediated IL-24 (Ad-IL24) gene therapy for neuroblastoma. We showed that Ad-IL24 effectively inhibited the proliferation of SH-SY5Y cells in vitro by conspicuously inducing apoptosis. To further explore the molecular mechanism by which Ad-IL24 induced apoptosis in SH-SY5Y tumor cells, we found that Ad-IL24 increased the expression of Bax and promoted the activation of caspase-3, while decreasing Bcl-2 levels. We also demonstrated that Ad-IL24 significantly inhibited tumor growth in vivo in a xenograft neuroblastoma tumor in athymic nude mice. In summary, Ad-IL24 overexpression exerted potent antitumor activity via inducing apoptosis in neuroblastoma cells."
According to the news reporters, the research concluded: "Therefore, IL-24 has the potential to serve as an agent for gene therapy in the treatment of neuroblastoma."
For more information on this research see: Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivo. Tumor Biology, 2013;34(4):2419-2426. Tumor Biology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Tumor Biology - www.springerlink.com/content/1010-4283/)
Our news journalists report that additional information may be obtained by contacting B.B. Zhuo, Xuzhou Medical College, Dept. of Ultrasound, Affiliated Hosp, Xuzhou 221002, Jiangsu, People's Republic of China. Additional authors for this research include R. Wang, Y.Y. Yin, H.W. Zhang, T.S. Ma, F.L. Liu, H. Cao and Y.C. Shi (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Jiangsu, Apoptosis, Xenograft, Gene Therapy, Therapeutics, Bioengineering, Xenotransplantion, Cell Proliferation, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC