"Exopolysaccharide of Shigella Sonnei Bacteria, Method for Producing Same, Vaccine and Pharmaceutical Composition Containing Same" in Patent Application Approval Process
Patent application serial number 877305 has not been assigned to a company or institution.
The following quote was obtained by the news editors from the background information supplied by the inventors: "Almost 100 years now after discovering the bacillus
"Relating to the aforementioned, WHO recommends as priority goal the development of a 'global' anti-shigella vaccine, including protective compounds for pathogenic bacteria of genus Shigella, specifically S. sonnei, phase I (Kotloff K. L., Winickoff J. P, Ivanoff B., Clemens J. D., Swerdlow D. L., Sansonetti P. J., Adak G. K., Levine M. M. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. WHO, 1999, v. 77, p. 651-665).
"Development of a monovaccine against shigellosis S.sonnei may be considered as a preliminary step for the solution of this general problem as an independent project extremely actual for many regions.
"The specificity of immunity to Shigella infection is determined by the structure of the Shigella's main protective antigen--the polysaccharide O-antigen. Primary structure of O-specific polysaccharide obtained from the lipopolysaccharide (LPS) molecule of S. sonnei, phase I identified by Kenne et al (
"O-antigen component of LPS is a polysaccharide composed of repeating disaccharide units of O-[4-amino-2-(N-acetyl)amino-2,4- dideoxy-.beta.-D-galactopyranosyl]-(1.fwdarw.4)-[2-(N-acetyl)amino-2-deox- y-.alpha.-L-altrpyranuronic acid] linked by .fwdarw.(.beta.) bonds to form a polysaccharide chain. This O-polysaccharide component of S. sonnei, phase I, covalently links to E.coli R2 type core domain, which, in turn, covalently links to lipid A and forming a linear molecule LPS.
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