By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Peptides. According to news reporting originating in Aveiro, Portugal, by NewsRx journalists, research stated, "Adsorbents based on single-bilayer graphene oxide sheet (hereafter termed 'graphene oxide') are widely used in contaminated environments cleanup which may easily open the avenues for their entry to different environmental compartments, exposure to organisms and their subsequent transfer to human/animal food chain. Considering a common food crop-faba bean (Vicia faba L.) germinating seedlings as a model plant system, this study assesses the V. faba-tolerance to different concentrations (0, 100, 200, 400, 800, and 1600 mg L-1) of graphene oxide (0.5-5 mu m) and evaluates glutathione (gamma-glutamyl-cysteinyl-glycine) redox system significance in this context."
The news reporters obtained a quote from the research from the University of Aveiro, "The results showed significantly increased V. faba sensitivity under three graphene oxide concentrations (in order of impact: 1,600 > 200 > 100 mg graphene oxide L-1), which was accompanied by decreased glutathione redox (reduced glutathione-to-oxidized glutathione) ratio, reduced glutathione pool, as well as significant and equally elevated activities of glutathione-regenerating (glutathione reductase) and glutathione-metabolizing (glutathione peroxidase; glutathione sulfo-transferase) enzymes. Contrarily, the two graphene oxide concentrations (in order of impact: 800 > 400 graphene oxide mg L-1) yielded promising results; where, significant improvements in V. faba health status (measured as increased graphene oxide tolerance) were clearly perceptible with increased ratio of the reduced glutathione-to-oxidized glutathione, reduced glutathione pool and glutathione reductase activity but decreased activities of glutathione-metabolizing enzymes."
According to the news reporters, the research concluded: "It is inferred that V. faba seedlings-sensitivity and/or tolerance to graphene oxide concentrations depends on both the cellular redox state (reduced glutathione-to-oxidized glutathione ratio) and the reduced glutathione pool which in turn are controlled by a finely tuned modulation of the coordination between glutathione-regenerating and glutathione-metabolizing enzymes."
For more information on this research see: Single-bilayer graphene oxide sheet tolerance and glutathione redox system significance assessment in faba bean (Vicia faba L.). Journal of Nanoparticle Research, 2013;15(7):192-203. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
Our news correspondents report that additional information may be obtained by contacting N.A. Anjum, University of Aveiro, Dept. of Biol, P-3810193 Aveiro, Portugal. Additional authors for this research include N. Singh, M.K. Singh, Z.A. Shah, A.C. Duarte, E. Pereira and I. Ahmad (see also Peptides).
Keywords for this news article include: Aveiro, Europe, Portugal, Glutathione, Oligopeptides, Enzymes and Coenzymes
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