Iranian researchers have devised a method to measure urea in blood plasma of dialytic patients by using polypyrrole nanostructured fiber through headspace solid phase microextraction.
The method can measure even very small concentrations of urea and it can be used rapidly,
The method can be used in future in other fields of medicine as well.
The researchers produced polypyrrole film with a nanometric structure on the surface of platinum electrode through electrochemical synthesis in aqueous environment under nitrogen atmosphere by using a system containing three electrodes.
Taking into consideration the low vapor pressure of urea, a sorbent with high area is required to yield the maximum amount of urea in headspace. The nanostructured fiber synthesized in this research has numerous pores and holes on its surface. Therefore, it is very appropriate to adsorb urea in the headspace.
The most important parameter in this method is the vapor pressure of the sample. The higher the vapor pressure of the compound, the better its conditions for measuring analyte.
The three parameters of high tendency of urea to proton, high concentration of the compound in serum samples and the use of nanostructured polypyrrole fiber have resolved the problem of low vapor pressure of the compound.
Results of the research have been published in Analytical and Bioanalytical Chemistry, vol. 405, issue 15, pp. 5,333-5,339.
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