By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Supramolecular Research. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "A new, efficient, and environmental friendly hollow fiber liquid phase microextraction (HF-LPME) method based on supramolecular solvents was developed for extraction of five benzodiazepine drugs. The supramolecular solvent was produced from coacervation of decanoic acid aqueous vesicles in the presence of tetrabutylammonium (Bu4N+)."
The news reporters obtained a quote from the research from Tarbiat Modares University, "In this work, benzodiazepines were extracted from aqueous samples into a supramolecular solvent impregnated in the wall pores and also filled inside the porous polypropylene hollow fiber membrane. The driving forces for the extraction were hydrophobic, hydrogen bonding, and pi-cation interactions between the analytes and the vesicular aggregates. High-performance liquid chromatography with photodiode array detection (HPLC-DAD) was applied for separation and determination of the drugs. Several parameters affecting the extraction efficiency including pH, hollow fiber length, ionic strength, stirring rate, and extraction time were investigated and optimized. Under the optimal conditions, the preconcentration factors were obtained in the range of 112-198. Linearity of the method was determined to be in the range of 1.0-200.0 mu g L-1 for diazepam and 2.0-200.0 mu g L-1 for other analytes with coefficient of determination (R-2) ranging from 0.9954 to 0.9993. The limits of detection for the target benzodiazepines were in the range of 0.5-0.7 mu g L-1."
According to the news reporters, the research concluded: "The method was successfully applied for extraction and determination of the drugs in water, fruit juice, plasma and urine samples and relative recoveries of the compounds studied were in the range of 90.0-98.8%."
For more information on this research see: Supramolecular solvent-based hollow fiber liquid phase microextraction of benzodiazepines. Analytica Chimica Acta, 2013;804():135-142. Analytica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Analytica Chimica Acta - www.elsevier.com/wps/product/cws_home/502681)
Our news correspondents report that additional information may be obtained by contacting F. Rezaei, Tarbiat Modares Univ, Dept. of Toxicol, Tehran, Iran. Additional authors for this research include Y. Yamini, M. Moradi and B. Daraei (see also Supramolecular Research).
Keywords for this news article include: Iran, Asia, Tehran, Nanotechnology, Emerging Technologies, Supramolecular Research
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