By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Current study results on Gastroenterology have been published. According to news reporting out of Tokyo, Japan, by VerticalNews editors, research stated, "In early stage drug development, it is desirable to assess the toxicity of compounds as quickly as possible. Biomarker genes can help predict whether a candidate drug will adversely affect a given individual, but they are often difficult to discover."
Our news journalists obtained a quote from the research from the University of Tokyo, "In addition, the mechanism of toxicity of many drugs and common compounds is not yet well understood. The Japanese Toxicogenomics Project provides a large database of systematically collected microarray samples from rats (liver, kidney and primary hepatocytes) and human cells (primary hepatocytes) after exposure to 170 different compounds in different dosages and at different time intervals. However, until now, no intuitive user interface has been publically available, making it time consuming and difficult for individual researchers to explore the data. We present Toxygates, a user-friendly integrated analysis platform for this database. Toxygates combines a large microarray dataset with the ability to fetch semantic linked data, such as pathways, compound-protein interactions and orthologs, on demand. It can also perform pattern-based compound ranking with respect to the expression values of a set of relevant candidate genes."
According to the news editors, the research concluded: "By using Toxygates, users can freely interrogate the transcriptome's response to particular compounds and conditions, which enables deep exploration of toxicity mechanisms."
For more information on this research see: Toxygates: interactive toxicity analysis on a hybrid microarray and linked data platform. Bioinformatics, 2013;29(23):3080-3086. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Bioinformatics - bioinformatics.oxfordjournals.org)
Our news journalists report that additional information may be obtained by contacting J. Nystrom-Persson, University of Tokyo, Center Knowledge Struct, Bunkyo Ku, Tokyo 1138656, Japan. Additional authors for this research include Y. Igarashi, M. Ito, M. Morita, N. Nakatsu, H. Yamada and K. Mizuguchi.
Keywords for this news article include: Asia, Tokyo, Japan, Gastroenterology, Information Technology, Information and Data Platforms
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