By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Electric Stimulation Therapy. According to news reporting from Memphis, Tennessee, by NewsRx journalists, research stated, "Conventional deep brain stimulation (DBS) devices continue to rely on an open-loop system in which stimulation is independent of functional neural feedback. The authors previously proposed that as the foundation of a DBS 'smart' device, a closed-loop system based on neurochemical feedback, may have the potential to improve therapeutic outcomes."
The news correspondents obtained a quote from the research from the University of Memphis, "Alterations in neurochemical release are thought to be linked to the clinical benefit of DBS, and fast-scan cyclic voltammetry (FSCV) has been shown to be effective for recording these evoked neurochemical changes. However, the combination of FSCV with conventional DBS devices interferes with he recording and identification of the evoked analytes. To integrate neurochemical recording with neurostimulation, the authors developed the Mayo Investigational Neuromodulation Control System (MINCS), a novel, wirelessly controlled stimulation device designed to interface with FSCV performed by their previously described Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). To test the functionality of these integrated devices, various frequencies of electrical stimulation were applied by MINCS to the medial forebrain bundle of the anesthetized rat, and striatal dopamine release was recorded by WINCS. The parameters for FSCV in the present study consisted of a pyramidal voltage waveform applied to the carbon-fiber microelectrode every 100 msec, ramping between -0.4 V and +1.5 V with respect to an Ag/AgCl reference electrode at a scan rate of either 400 V/sec or 1000 V/sec. The carbon-fiber microelectrode was held at the baseline potential of -0.4 V between scans. By using MINCS in conjunction with WINCS coordinated through an optic fiber, the authors interleaved intervals of electrical stimulation with FSCV scans and thus obtained artifact-free wireless FSCV recordings. Electrical stimulation of the medial forebrain bundle in the anesthetized rat by MINCS elicited striatal dopamine release that was time-locked to stimulation and increased progressively with stimulation frequency. Here, the authors report a series of proof-of-principle tests in the rat brain demonstrating MINCS to be a reliable and flexible stimulation device that, when used in conjunction with WINCS, performs wirelessly controlled stimulation concurrent with artifact-free neurochemical recording."
According to the news reporters, the research concluded: "These findings suggest that the integration of neurochemical recording with neurostimulation may be a useful first step toward the development of a closed-loop DBS system for human application."
For more information on this research see: Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation Laboratory investigation. Journal of Neurosurgery, 2013;119(6):1556-1565. Journal of Neurosurgery can be contacted at: Amer Assoc Neurological Surgeons, 5550 Meadowbrook Drive, Rolling Meadows, IL 60008, USA (see also Electric Stimulation Therapy).
Our news journalists report that additional information may be obtained by contacting S.Y. Chang, University of Memphis, Dept. of Psychol, Memphis, TN 38152, United States. Additional authors for this research include C.J. Kimble, I. Kim, S.B. Paek, K.R. Kressin, J.B. Boesche, S.V. Whitlock, D.R. Eaker, A. Kasasbeh, A.E. Horne, C.D. Blaha, K.E. Bennet and K.H. Lee.
Keywords for this news article include: Memphis, Tennessee, Chemistry, Therapeutics, United States, Electrochemical, Deep Brain Stimulation, North and Central America, Electric Stimulation Therapy
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