By a News Reporter-Staff News Editor at Gastroenterology Week -- Researchers detail new data in Endocrinology. According to news reporting originating from Indianapolis, Indiana, by NewsRx correspondents, research stated, "Inorganic materials have properties that can be advantageous in bioencapsulation for cell transplantation. Our aim was to engineer a hybrid inorganic/soft tissue construct by inducing pancreatic islets to grow an inorganic shell."
Our news editors obtained a quote from the research from the Indiana University School of Medicine, "We created pancreatic islets surrounded by porous silica, which has potential application in the immunoprotection of islets in transplantation therapies for type 1 diabetes. The new method takes advantage of the islet capsule surface as a template for silica formation. Mouse and human islets were exposed to medium containing saturating silicic acid levels for 9-15 min. The resulting tissue constructs were then cultured for up to 4 wk under normal conditions. Scanning electron microscopy and energy dispersive X-ray spectroscopy was used to monitor the morphology and elemental composition of the material at the islet surface. A cytokine assay was used to assess biocompatibility with macrophages."
According to the news editors, the research concluded: "Islet survival and function were assessed by confocal microscopy, glucose-stimulated insulin release assays, oxygen flux at the islet surface, expression of key genes by RT-PCR, and syngeneic transplant into diabetic mice."
For more information on this research see: Mouse and human islets survive and function after coating by biosilicification. American Journal of Physiology-Endocrinology and Metabolism, 2013;305(10):E1230-E1240. American Journal of Physiology-Endocrinology and Metabolism can be contacted at: Amer Physiological Soc, 9650 Rockville Pike, Bethesda, MD 20814, USA (see also Endocrinology).
The news editors report that additional information may be obtained by contacting D.B. Jaroch, Indiana Univ Sch Med, Dept. of Cellular & Integrat Physiol, Indianapolis, IN 46202, United States. Additional authors for this research include J. Lu, R. Madangopal, N.D. Stull, M. Stensberg, J. Shi, J.L. Kahn, R. Herrera-Perez, M. Zeitchek, J. Sturgis, J.P. Robinson, M.C. Yoder, D.M. Porterfield, R.G. Mirmira and J.L. Rickus.
Keywords for this news article include: Indianapolis, United States, Endocrinology, North and Central America
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