By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news reporting out of Santa Barbara, California, by NewsRx editors, research stated, "E-cadherin plays a pivotal role in tissue morphogenesis by forming clusters that support intercellular adhesion and transmit tension. What controls E-cadherin mesoscopic organization in clusters is unclear."
Our news journalists obtained a quote from the research from the University of California, "We use 3D superresolution quantitative microscopy in Drosophila embryos to characterize the size distribution of E-cadherin nanometric clusters. The cluster size follows power-law distributions over three orders of magnitude with exponential decay at large cluster sizes. By exploring the predictions of a general theoretical framework including cluster fusion and fission events and recycling of E-cadherin, we identify two distinct active mechanisms setting the cluster-size distribution. Dynamin-dependent endocytosis targets large clusters only, thereby imposing a cutoff size. Moreover, interactions between E-cadherin clusters and actin filaments control the fission in a size-dependent manner. E-cadherin clustering depends on key cortical regulators, which provide tunable and local control over E-cadherin organization."
According to the news editors, the research concluded: "Our data provide the foundation for a quantitative understanding of how E-cadherin distribution affects adhesion and might regulate force transmission in vivo."
For more information on this research see: Principles of E-Cadherin Supramolecular Organization In Vivo. Current Biology, 2013;23(22):2197-2207. Current Biology can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Current Biology - www.elsevier.com/wps/product/cws_home/601284)
Our news journalists report that additional information may be obtained by contacting B.A.T. Quang, University of California, Dept. of Phys, Santa Barbara, CA 93101, United States. Additional authors for this research include M. Mani, O. Markova, T. Lecuit and P.F. Lenne (see also Proteins).
Keywords for this news article include: Cadherins, California, Santa Barbara, United States, Glycoproteins, Nanotechnology, Supramolecular, Membrane Proteins, Emerging Technologies, Cell Adhesion Molecules, North and Central America
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