By a News Reporter-Staff News Editor at Journal of Engineering -- A new study on Cytoskeleton is now available. According to news reporting originating from Paris, France, by VerticalNews correspondents, research stated, "Intracellular biochemical reactions are often localized in space and time, inducing gradients of enzymatic activity that may play decisive roles in determining cell's fate and functions. However, the techniques available to examine such enzymatic gradients of activity remain limited."
Our news editors obtained a quote from the research from National Center for Scientific Research (CNRS), "Here, we propose a new method to engineer a spatial gradient of signaling protein concentration within Xenopus egg extracts using superparamagnetic nanoparticles. We show that, upon the application of a magnetic field, a concentration gradient of nanoparticles with a tunable length extension is established within confined egg extracts. We then conjugate the nanoparticles to RanGTP, a small G-protein controlling microtubule assembly. We found that the generation of an artificial gradient of Ran-nanoparticles modifies the spatial positioning of microtubule assemblies. Furthermore, the spatial control of the level of Ran concentration allows us to correlate the local fold increase in Ran-nanoparticle concentration with the spatial positioning of the microtubule-asters. Our assay provides a bottom-up approach to examine the minimum ingredients generating polarization and symmetry breaking within cells."
According to the news editors, the research concluded: "More generally, these results show how magnetic nanoparticles and magnetogenetic tools can be used to control the spatiotemporal dynamics of signaling pathways."
For more information on this research see: Engineering Spatial Gradients of Signaling Proteins Using Magnetic Nanoparticles. Nano Letters, 2013;13(11):5147-5152. Nano Letters can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Nano Letters - www.pubs.acs.org/journal/nalefd)
The news editors report that additional information may be obtained by contacting L. Bonnemay, Ecole Normale Super, Dept. of Chim, CNRS, UPMCUMR 8640, F-75005 Paris, France. Additional authors for this research include S. Hostachy, C. Hoffmann, J. Gautier and Z. Gueroui.
Keywords for this news article include: Paris, France, Europe, Peptides, Proteins, Cytoplasm, Amino Acids, Engineering, Cytoskeleton, Microtubules, Nanoparticle, Nanotechnology, Cellular Structures, Intracellular Space, Emerging Technologies
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