Our news editors obtained a quote from the research from Sanofi Pasteur, "In this study, we demonstrated the use of dynamic light scattering (DLS) to monitor inclusion body (IB) solubilization, protein refolding, and aggregation near the production line of a recombinant protein-based vaccine candidate. Our results were in good agreement with those measured by size-exclusion chromatography. DLS was also used to characterize the mechanism of aggregation."
According to the news editors, the research concluded: "As DLS is a quick, nonperturbing technology, it can potentially be used as an at-line process analytical technology to ensure complete IB solubilization and aggregate-free refolding."
For more information on this research see: Utilizing Dynamic Light Scattering as a Process Analytical Technology for Protein Folding and Aggregation Monitoring in Vaccine Manufacturing.
The news editors report that additional information may be obtained by contacting Z. Yu, Sanofi Pasteur, Bioproc Res & Dev,
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