By a News Reporter-Staff News Editor at Journal of Technology -- Current study results on Microscopy and Microanalysis have been published. According to news originating from West Lafayette, Indiana, by VerticalNews correspondents, research stated, "Mass transport within collagen-based matrices is critical to tissue development, repair, and pathogenesis, as well as the design of next-generation tissue engineering strategies. This work shows how collagen precursors, specified by intermolecular cross-link composition, provide independent control of collagen matrix mechanical and transport properties."
Our news journalists obtained a quote from the research from Purdue University, "Collagen matrices were prepared from tissue-extracted monomers or oligomers. Viscoelastic behavior was measured in oscillatory shear and unconfined compression. Matrix permeability and diffusivity were measured using gravity-driven permeametry and integrated optical imaging, respectively. Both collagen types showed an increase in stiffness and permeability hindrance with increasing collagen concentration (fibril density); however, different physical property-concentration relationships were noted. Diffusivity was not affected by concentration for either collagen type over the range tested. In general, oligomer matrices exhibited a substantial increase in stiffness and only a modest decrease in transport properties when compared with monomer matrices prepared at the same concentration. The observed differences in viscoelastic and transport properties were largely attributed to increased levels of interfibril branching within oligomer matrices."
According to the news editors, the research concluded: "The ability to relate physical properties to relevant microstructure parameters, including fibril density and interfibril branching, is expected to advance the understanding of cell-matrix signaling, as well as facilitate model-based prediction and design of matrix-based therapeutic strategies."
For more information on this research see: Oligomers modulate interfibril branching and mass transport properties of collagen matrices. Microscopy and Microanalysis, 2013;19(5):1323-33. (Cambridge University Press - www.cambridge.org; Microscopy and Microanalysis - journals.cambridge.org/action/displayJournal?jid=MAM)
The news correspondents report that additional information may be obtained from C.F. Whittington, Weldon School of Biomedical Engineering, College of Engineering, Purdue University, West Lafayette, IN 47907, United States. Additional authors for this research include E. Brandner, K.Y. Teo, B. Han, E. Nauman and S.L Voytik-Harbin.
Keywords for this news article include: Indiana, United States, West Lafayette, North and Central America, Microscopy and Microanalysis.
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