By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Data detailed on Bioinformatics have been presented. According to news originating from Helsinki, Finland, by VerticalNews correspondents, research stated, "Current high-throughput sequencing technologies allow cost-efficient genotyping of millions of single nucleotide polymorphisms (SNPs) for hundreds of samples. However, the tools that are currently available for constructing linkage maps are not well suited for large datasets."
Our news journalists obtained a quote from the research from the University of Helsinki, "Linkage maps of large datasets would be helpful in de novo genome assembly by facilitating comprehensive genome validation and refinement by enabling chimeric scaffold detection, as well as in family-based linkage and association studies, quantitative trait locus mapping, analysis of genome synteny and other complex genomic data analyses. We describe a novel tool, called Lepidoptera-MAP (Lep-MAP), for constructing accurate linkage maps with ultradense genome-wide SNP data. Lep-MAP is fast and memory efficient and largely automated, requiring minimal user interaction. It uses simultaneously data on multiple outbred families and can increase linkage map accuracy by taking into account achiasmatic meiosis, a special feature of Lepidoptera and some other taxa with no recombination in one sex (no recombination in females in Lepidoptera). We demonstrate that Lep-MAP outperforms other methods on real and simulated data. We construct a genome-wide linkage map of the Glanville fritillary butterfly (Melitaea cinxia) with over 40 000 SNPs."
According to the news editors, the research concluded: "The data were generated with a novel in-house SOLiD restriction site-associated DNA tag sequencing protocol, which is described in the online supplementary material."
For more information on this research see: Lep-MAP: fast and accurate linkage map construction for large SNP datasets. Bioinformatics, 2013;29(24):3128-3134. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Bioinformatics - bioinformatics.oxfordjournals.org)
The news correspondents report that additional information may be obtained from P. Rastas, University of Helsinki, Inst Biotechnol, FI-00014 Helsinki, Finland. Additional authors for this research include L. Paulin, I. Hanski, R. Lehtonen and P. Auvinen.
Keywords for this news article include: Europe, Finland, Helsinki, Bioinformatics
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC