By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Oncology. According to news originating from Recife, Brazil, by NewsRx correspondents, research stated, "Cell surface glycoconjugates play an important role in differentiation/dedifferentiation processes and lectins are employed to evaluate them by several methodologies. Fluorescent probes are considered a valuable tool because of their ability to provide a particular view, and are more detailed and sensitive in terms of cell structure and molecular content."
Our news journalists obtained a quote from the research from Federal University, "The aim of this study was to evaluate and compare the expression and distribution of glycoconjugates in normal human breast tissue, and benign (fibroadenoma), and malignantly transformed (invasive ductal carcinoma) breast tissues. For this, we used mercaptosuccinic acid-coated Cadmium Telluride (CdTe) quantum dots (QDs) conjugated with concanavalin A (Con A) or Ulex europaeus agglutinin I (UEA I) lectins to detect alpha-D-glucose/mannose and L-fucose residues, respectively. The QD-lectin conjugates were evaluated by hemagglutination activity tests and carbohydrate inhibition assays, and were found to remain functional, keeping their fluorescent properties and carbohydrate recognition ability. Fluorescence images showed that different regions of breast tissue expressed particular types of carbohydrates."
According to the news editors, the research concluded: "While the stroma was preferentially and intensely stained by QD-Con A, ductal cells were preferentially labeled by QD-UEA I. These results indicate that QD-lectin conjugates can be used as molecular probes and can help to elucidate the glycoconjugate profile in biological processes."
For more information on this research see: Evaluation of glycophenotype in breast cancer by quantum dot-lectin histochemistry. International Journal of Nanomedicine, 2013;8():4623-4629. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).
The news correspondents report that additional information may be obtained from C.G. Andrade, Federal University of Pernambuco, Pharmaceut Sci Department, Recife, PE, Brazil. Additional authors for this research include P.E. Cabral, D.P.L. Tenorio, B.S. Santos, E.I.C. Beltrao, A. Fontes and L.B. Carvalho.
Keywords for this news article include: Recife, Brazil, Oncology, Quantum Dots, South America, Breast Cancer, Nanotechnology, Women's Health, Emerging Technologies
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