By a News Reporter-Staff News Editor at Science Letter -- Current study results on Science have been published. According to news reporting from Urbana, Illinois, by NewsRx journalists, research stated, "A form of microscopy that utilizes a photonic crystal biosensor surface as a substrate for cell attachment enables label-free, quantitative, submicron resolution, time-resolved imaging of cell-surface interactions without cytotoxic staining agents or temporally-unstable fluorophores. Other forms of microscopy do not provide this direct measurement of live cell-surface attachment localization and strength that includes unique, dynamic morphological signatures critical to the investigation of important biological phenomena such as stem cell differentiation, chemotaxis, apoptosis, and metastasis."
The news correspondents obtained a quote from the research from the University of Illinois, "Here, we introduce Photonic Crystal Enhanced Microscopy (PCEM), and apply it to the study of murine dental stem cells to image the evolution of cell attachment and morphology during chemotaxis and drug-induced apoptosis. PCEM provides rich, dynamic information about the evolution of cell-surface attachment profiles over biologically relevant time-scales."
According to the news reporters, the research concluded: "Critically, this method retains the ability to monitor cell behavior with spatial resolution sufficient for observing both attachment footprints of filopodial extensions and intracellular attachment strength gradients."
For more information on this research see: Photonic crystal enhanced microscopy for imaging of live cell adhesion. Analyst, 2013;138(20):5886-94. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)
Our news journalists report that additional information may be obtained by contacting W. Chen, Dept. of Electrical and Computer Engineering, Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, 208 North Wright Street, Urbana, IL 61801, United States. Additional authors for this research include K.D. Long, M. Lu, V. Chaudhery, H. Yu, J.S. Choi, J. Polans, Y. Zhuo, B.A. Harley and B.T Cunningham (see also Science).
Keywords for this news article include: Urbana, Science, Illinois, United States, North and Central America.
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