By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating in Utrecht, Netherlands, by NewsRx journalists, research stated, "Gene therapy has the potential to provide therapeutic benefits to hepatocellular carcinoma (HCC) patients and has been the subject of intense pre-clinical and clinical research in recent years. In HCC, delivery of gene therapy has been attempted through multiple routes, using many vectors and genes in both animal models and patients."
The news reporters obtained a quote from the research from University Medical Center, "Unfortunately, a highly effective gene therapy for HCC has not been reported so far. The efficiency and selectivity of the gene transfer to the tumor tissue is too low. A great proportion of the failure can be attributed to the gene/vector complex itself. However, there is certainly a critical role played by the delivery technique. In the last decade a large amount of studies has been conducted to develop the ideal gene delivery technique for HCC, though questions regarding safety, repeatability, and efficiency still linger. The aim of this article is to review gene delivery techniques for HCC. It focuses on the relationship between the gene/vector complex and the delivery technique at promoting efficacy of gene therapy, without the cost of unacceptable systemic toxicity. The delivery techniques include systemic intravenous (IV) injection, intra-arterial (IA) injection, intra-tumoral (IT) injection, intra-portal (IF) injection, intra-biliary (IB) delivery and intra-splenic (IS) injection."
According to the news reporters, the research concluded: "The relative merits of each of these techniques are herein analyzed and discussed."
For more information on this research see: Delivery Approaches of Gene Therapy in Hepatocellular Carcinoma. Anticancer Research, 2013;33(11):4711-4718. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research - www.iiar-anticancer.org/; Anticancer Research - www.iiar-anticancer.org/main.php?id=2)
Our news correspondents report that additional information may be obtained by contacting F. Duan, Univ Med Center Utrecht, Dept. of Radiol & Nucl Med, Utrecht, Netherlands (see also Biotechnology).
Keywords for this news article include: Biotechnology, Europe, Utrecht, Genetics, Oncology, Netherlands, Cancer Gene Therapy, Hepatocellular Carcinoma
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