By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Analytical Chemistry have been presented. According to news originating from Nanjing, People's Republic of China, by NewsRx correspondents, research stated, "Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer (EMMPRIN), plays an essential role in tumor progression and metastasis, the expression of which on cell surface is a critical clinical testing index for cancer therapy. In this work, an electrochemical method to assay CD147/EMMPRIN expression on tumor cell surface is proposed."
Our news journalists obtained a quote from the research from Nanjing University, "While the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) catalyzed by horseradish peroxidase (HRP) can be employed for electrochemical measurement, the signal enhancement amplified by gold nanoparticles (GNPs) can be also utilized in this study. Therefore, under optimized conditions, the fabricated biosensor responds linearly to the CD147/EMMPRIN concentration from 125 to 1000 pg/mL with a detection limit as low as 52 pg/mL. High sensitivity can also be achieved for the quantification of breast cancer cells in a linear range from 6.2 x 10(4) to 6.25 x 10(5) cells/mL. Moreover, the CD147/EMMPRIN expressed on a single breast cancer cell can be calculated as 2.57 x 10(4) molecules/cell."
According to the news editors, the research concluded: "The proposed strategy in this study is considerably potential for monitoring the dynamic protein expression on cancer cells and for the effective cancer diagnosis and treatment in the future."
For more information on this research see: Sensitive detection of CD147/EMMPRIN and its expression on cancer cells with electrochemical technique. Talanta, 2013;105():187-91. (Elsevier - www.elsevier.com; Talanta - www.elsevier.com/wps/product/cws_home/525438)
The news correspondents report that additional information may be obtained from D. Zheng, Dept. of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Taiwan. Additional authors for this research include X. Zhu, X. Ding, X. Zhu, Y. Yin and G. Li (see also Analytical Chemistry).
Keywords for this news article include: Asia, Cancer, Nanjing, Oncology, Electrochemical, Analytical Chemistry, People's Republic of China.
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