By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting from Philadelphia, Pennsylvania, by NewsRx journalists, research stated, "Bladder cancer stem cells (BCSCs) may be the source for tumorigenesis, recurrence, and resistance to treatment of bladder carcinoma. Lysine-specific demethylase 1 (LSD1) plays crucial roles in the pluripotency maintenance of embryonic and cancer stem cells through the epigenetical modification of the associated genes, such as the regulation of bivalent domain at regulatory region of the developmental genes."
The news correspondents obtained a quote from the research from the Department of Biomedical Sciences, "It has also been found that LSD1 expression is elevated in clinical bladder cancer tissues compared with in normal tissues, and LSD1 knock down could significantly result in the suppression of bladder cancer cell line proliferation. Furthermore, results from our unpublished study showed that elevated levels of LSD1 are highly associated with the grades of the cancers, and more interestingly, LSD1 was mainly presented in the basal layer of bladder carcinoma tissue, co-localizing with BCSCs. Thus we hypothesized that LSD1 is mainly expressed in BCSCs in bladder cancer tissues, and LSD1-mediated epigenetic modification of the developmental genes may play important roles in maintaining pluripotency of BCSCs."
According to the news reporters, the research concluded: "LSD1 may become a reliable prognostic indicator and could serve as a molecular target in bladder cancer therapy."
For more information on this research see: The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells. Medical Hypotheses, 2013;81(5):823-825. Medical Hypotheses can be contacted at: Churchill Livingstone, Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh EH1 3AF, Midlothian, Scotland. (Elsevier - www.elsevier.com; Medical Hypotheses - www.elsevier.com/wps/product/cws_home/623059)
Our news journalists report that additional information may be obtained by contacting W.H. Lan, Philadelphia Coll Osteopath Med, Dept. of Biomed Sci, Philadelphia, PA 19131, United States. Additional authors for this research include D.Z. Zhang and J. Jiang (see also Biotechnology).
Keywords for this news article include: Biotechnology, Genetics, Oncology, Carcinoma, Philadelphia, Pennsylvania, United States, Bladder Cancer, Stem Cell Research, Cancer Gene Therapy, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC