By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Science. According to news reporting out of Kolkata, India, by NewsRx editors, research stated, "The presence of magnetic nanoparticles (NPs) in physiological systems induces toxicity through its effects on mitochondrial function and reactive oxygen species (ROS) imbalance. Magnetic NP induced cytotoxicity has been elaborately evaluated for impending threats, however, a detailed investigation is lacking."
Our news journalists obtained a quote from the research from Central Glass and Ceramic Research Institute, "It is shown that the interaction of Fe3O4 NPs with cytochrome c can lead to different events based on the NPs to protein ratio, the solution conditions, and the type of surface protection. At low NPs concentration, rapid binding and subsequent electron transfer are the preferred events while at higher concentration slow oxidative modification of the protein is initiated. The slow event of protein modification yields conformational disorientation, loss of stability, and formation of amyloid-like structures with cytochrome c. The possibility that the NP induced oxidative stress and age can work in concert to compromise different aspects of cellular quality control processes is discussed."
According to the news editors, the research concluded: "Suitable surface modifications of the NPs inhibit their direct binding to the protein molecules and minimize NP induced toxicity."
For more information on this research see: Surface Coating Rescues Proteins from Magnetite Nanoparticle Induced Damage. Particle & Particle Systems Characterization, 2013;30(8):683-694. Particle & Particle Systems Characterization can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Particle & Particle Systems Characterization - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4117)
Our news journalists report that additional information may be obtained by contacting N. Joshi, CSIR, Cent Glass & Ceram Res Inst, Nanostruct Mat Div, Kolkata 700032, India. Additional authors for this research include A. Mukhopadhyay, S. Basak, G. De and K. Chattopadhyay (see also Science).
Keywords for this news article include: Asia, India, Kolkata, Science, Peptides, Proteins, Amino Acids
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