By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Epithelial Cells. According to news reporting originating from Singapore, Singapore, by NewsRx correspondents, research stated, "Silica nanoparticles (SiO2 NPs) are one of the most widely used engineered nanoparticles and can been found in a wide range of consumer products. Despite their massive global production scale, little is known about their potential effects in the context of unintended exposure or ingestion."
Our news editors obtained a quote from the research from Nanyang Technological University, "Using TR146 cells as an in vitro model of the human oral buccal mucosa, the uptake, spatial intracellular distribution, reactive oxygen species (ROS) production, inflammatory response, and cytotoxic effects of commercial SiO2 NPs are examined. SiO2 NPs are shown to dock and cross the cellular membrane barrier in a dose-time-dependent manner. Confocal sectioning reveals translocation of SiO2 NPs into the cell nucleus after 12 h of exposure. A concentration threshold of more than 500 x 10(-6) m is observed, above which SiO2 NPs are shown to exert significant oxidative stress with concomitant upregulation of inflammatory genes IL6 and TNFA. Further analysis of the p53 pathway and a series of apoptotic and cell cycle biomarkers reveals intracellular accumulation of SiO2 NPs exert marginal nanotoxicity."
According to the news editors, the research concluded: "Collectively, this study provides important information regarding the uptake, intracellular distribution, and potential adverse cellular effects of SiO2 NPs commonly found in consumer products in the human oral epithelium."
For more information on this research see: Reciprocal Response of Human Oral Epithelial Cells to Internalized Silica Nanoparticles. Particle & Particle Systems Characterization, 2013;30(9):784-793. Particle & Particle Systems Characterization can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Particle & Particle Systems Characterization - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4117)
The news editors report that additional information may be obtained by contacting C.Y. Tay, Nanyang Technological University, Sch Mat Sci & Engn, Singapore 639798, Singapore. Additional authors for this research include W.R. Fang, M.I. Setyawati, C.P. Sum, J.P. Xie, K.W. Ng, X.D. Chen, C.H.L. Hong and D.T. Leong (see also Epithelial Cells).
Keywords for this news article include: Asia, Nanoparticle, Nanotechnology, Epithelial Cells, Silicon Nanocrystals, Emerging Technologies
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