By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Macromolecular Research. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "Viral nanoparticles (VNPs) have shown great potential as platforms for biomedical applications. Before using VNPs for further biomedical applications, it is important to clarify their biological behavior in vivo, which is rare for rodlike VNPs."
The news reporters obtained a quote from the research from Peking University, "In this paper, a study of tobacco mosaic virus (TMV), a typical rod-like VNP, is performed on blood clearance kinetics, biodistributions in both normal and tumor-bearing mice, histopathology and cytotoxicity. TMV was radiolabeled with I-125 using Iodogen method for in vivo quantitative analysis and imaging purpose. In the normal mice, the accumulation of TMV in the immune system led to a rapid blood clearance. The uptake of TMVs in the liver was less than that in the spleen, which is opposite to the results observed in the case of spherical VNPs. No signs of overt toxicity were observed in examined tissues according to the results of histological analysis."
According to the news reporters, the research concluded: "In addition, similar biodistribution patterns were observed in U87MG tumor-bearing mice."
For more information on this research see: Biobehavior in Normal and Tumor-Bearing Mice of Tobacco Mosaic Virus. Biomacromolecules, 2013;14(11):4032-4037. Biomacromolecules can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)
Our news correspondents report that additional information may be obtained by contacting M. Wu, Peking University, Medical & Hlth Analyt Center, Beijing 100191, People's Republic of China. Additional authors for this research include J.Y. Shi, D. Fan, Q. Zhou, F. Wang, Z.W. Niu and Y. Huang (see also Macromolecular Research).
Keywords for this news article include: Asia, Beijing, Viruses, Virology, Macromolecular Research, People's Republic of China
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