By a News Reporter-Staff News Editor at Diabetes Week -- Current study results on Diabetes have been published. According to news reporting from Denver, Colorado, by NewsRx journalists, research stated, "Silver is a commonly used topical antimicrobial. However, technologies to immobilize silver at the wound surface are lacking, while currently available silver-containing wound dressings release excess silver that can be cytotoxic and impair wound healing."
The news correspondents obtained a quote from the research from the University of Colorado, "We have shown that precise concentrations of silver at lower levels can be immobilized into a wound bed using a polyelectrolyte multilayer attachment technology. These silver nanoparticle-impregnated polyelectrolyte multilayers are noncytotoxic yet bactericidal in vitro, but their effect on wound healing in vivo was previously unknown. The purpose of this study was to determine the effect on wound healing of integrating silver nanoparticle/polyelectrolyte multilayers into the wound bed. A full-thickness, splinted, excisional murine wound healing model was employed in both phenotypically normal mice and spontaneously diabetic mice (healing impaired model). Gross image measurements showed an initial small lag in healing in the silver-treated wounds in diabetic mice, but no difference in time to complete wound closure in either normal or diabetic mice. Histological analysis showed modest differences between silver-treated and control groups on day 9, but no difference between groups at the time of wound closure. We conclude that silver nanoparticle/polyelectrolyte multilayers can be safely integrated into the wound beds of both normal and diabetic mice without delaying wound closure, and with transient histological effects."
According to the news reporters, the research concluded: "The results of this study suggest the feasibility of this technology for use as a platform to affect nanoscale wound engineering approaches to microbial prophylaxis or to augment wound healing."
For more information on this research see: Integration of Silver Nanoparticle-impregnated Polyelectrolyte Multilayers Into Murine-Splinted Cutaneous Wound Beds. Journal of Burn Care & Research, 2013;34(6):E359-E367. Journal of Burn Care & Research can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Journal of Burn Care & Research - journals.lww.com/burncareresearch/pages/default.aspx)
Our news journalists report that additional information may be obtained by contacting K.M. Guthrie, University of Colorado, Sch Med, Dept. of Surg, Denver, CO, United States. Additional authors for this research include A. Agarwal, L.B.C. Teixeira, R.R. Dubielzig, N.L.Abbott, C.J. Murphy, H. Singh, J.F. McAnulty and M.J. Schurr (see also Diabetes).
Keywords for this news article include: Denver, Colorado, Diabetes, Technology, United States, Endocrinology, North and Central America
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