By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Fullerenes have been published. According to news reporting originating in Cluj Napoca, Romania, by NewsRx journalists, research stated, "Recent data in the literature support the role of nicotinamide (NA) as a pharmacologic agent that stimulates pancreatic beta-cells to produce insulin in vitro. There are data showing that carbon nanotubes may be useful in initiating and maintaining cellular metabolic responses."
The news reporters obtained a quote from the research from the Iuliu Hatieganu University of Medicine and Pharmacy, "This study shows that administration of multiwalled carbon nanotubes (MWCNTs) functionalized with nicotinamide (NA-MWCNTs) leads to significant insulin production compared with individual administration of NA, MWCNTs, and a control solution. Treatment of 1.4E7 cells for 30 minutes with NA-MWCNTs at concentrations ranging from 1 mg/L to 20 mg/L resulted in significantly increased insulin release (0.18 ± 0.026 ng/mL for 1 mg/L, 0.21 ± 0.024 ng/mL for 5 mg/L, and 0.27 ± 0.028 ng/mL for 20 mg/L). Thus, compared with cells treated with NA only (0.1 ± 0.01 ng/mL for 1 mg/L, 0.12 ± 0.017 ng/mL for 5 mg/L, and 0.17 ± 0.01 ng/mL for 20 mg/L) we observed a significant positive effect on insulin release in cells treated with NA-MWCNTs. The results were confirmed using flow cytometry, epifluorescence microscopy combined with immunochemistry staining, and enzyme-linked immunosorbent assay techniques. In addition, using immunofluorescence microscopy techniques, we were able to demonstrate that MWCNTs enhance insulin production via the macrophage migration inhibitory factor pathway."
According to the news reporters, the research concluded: "The application and potential of NA combined with MWCNTs as an antidiabetic agent may represent the beginning of a new chapter in the nanomediated treatment of diabetes mellitus."
For more information on this research see: Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway. International Journal of Nanomedicine, 2013;8():3345-53 (see also Fullerenes).
Our news correspondents report that additional information may be obtained by contacting I. Ilie, Dept. of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Additional authors for this research include R. Ilie, T. Mocan, F. Tabaran, C. Iancu and L. Mocan.
Keywords for this news article include: Europe, Romania, Pancreas, Treatment, Fullerenes, Cluj Napoca, Carbon Nanotubes, Gastroenterology.
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