By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Gram-Positive Bacterial Infections have been presented. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Rapid, reliable recognition and detection of bacteria from an authentic specimen have been gained increasing interests in the past decades. Various materials have been designed and prepared for implementation of bacterial recognition and treatment in the artificial systems."
The news correspondents obtained a quote from the research from National Center for Nanoscience and Technology, "However, in the complicated physiological condition, the macrophages always compromise the outcomes of bacterial detection and/or treatment. In this work, we demonstrated the vancomycin-modified mesoporous silica nanoparticles (MSNsCVan) for efficiently targeting and killing gram-positive bacteria over macrophage-like cells. Owing to the specific hydrogen bonding interactions of vancomycin toward the terminal D-alanyl-D-alanine moieties of gram-positive bacteria, the MSNsCVan exhibited enhanced recognition for gram-positive bacteria due to the multivalent hydrogen binding effect. Furthermore, the fluorescent molecules (FITC) were covalently decorated inside of mesopores of MSNs for tracking and visualizing the MSNsCVan during the detection/treatment processes. Upon incubation of FITC decorated MSNs with bacteria (i.e., S. aureus and E. coli as gram-positive and gram-negative bacteria, respectively) or macrophage-like cells (Raw 264.7), the fluorescence signals in S. aureus were 2-4 times higher than that in E. coli and no detectable fluorescence signals were observed in Raw 264.7 cells under the same condition. Finally, the MSNsCVan showed unambiguous antibacterial efficacy without decrease in cell viability of macrophage-like cells."
According to the news reporters, the research concluded: "This new strategy opens a new door for specific detection and treatment of pathogenic bacteria with minimized side effects."
For more information on this research see: Vancomycin-Modified Mesoporous Silica Nanoparticles for Selective Recognition and Killing of Pathogenic Gram-Positive Bacteria Over Macrophage-Like Cells. ACS Applied Materials & Interfaces, 2013;5(21):10874-10881. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting G.B. Qi, Natl Center Nanosci & Technol NCNST, Lab Biol Effects Nanomat & Nanosafe, Beijing 100090, People's Republic of China. Additional authors for this research include L.L. Li, F.Q. Yu and H. Wang (see also Gram-Positive Bacterial Infections).
Keywords for this news article include: Asia, Beijing, Treatment, Immunology, Vancomycin, Macrophages, Nanoparticle, Glycopeptides, Myeloid Cells, Nanotechnology, Silicon Nanocrystals, Emerging Technologies, Connective Tissue Cells, People's Republic of China, Mononuclear Phagocyte System, Gram-Positive Bacterial Infections
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