By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Nanoparticles. According to news reporting originating from Kwangju, South Korea, by NewsRx correspondents, research stated, "A new approach to the surface engineering of superparamagnetic iron oxide nanoparticles (SPIONs) may encourage their development for clinical use. In this study, we demonstrated that nonpolymeric surface modification of SPIONs has the potential to be an advanced biocompatible contrast agent for biomedical applications, including diagnostic imaging in vivo."
Our news editors obtained a quote from the research from Chonnam National University, "Adenosine triphosphate (ATP), which is an innate biomaterial derived from the body, was coated onto the surface of SPIONs. An in vivo degradation study of ATP-coated SPIONs (ATP@SPIONs) was performed for 28 d. To diminish phagocytosis, ATP@SPIONs were surface-modified with gluconic acid. We next studied the ability of the SPIONs to serve as a specific targeted contrast agent after conjugation of cMet-binding peptide. The SPIONs were conjugated with Cy5.5 and labeled with 125I for multimodality imaging. In vivo and in vitro tumor-targeted binding studies were performed on U87MG cells or a U87MG tumor model using animal SPECT/CT, an optical imaging system, and a 1.5-T clinical MR scanner. ATP@SPIONs showed rapid degradation in vivo and in vitro, compared with ferumoxides. ATP@SPIONs modified with gluconic acid reduced phagocytic uptake, showed improved biodistribution, and provided good targetability in vivo. The gluconic acid-conjugated ATP@SPIONs, when conjugated with cMet-binding peptide, were successfully visualized on the U87MG tumors implanted in mice via multimodality imaging. We suggest that ATP@ SPIONs can be used as a multiplatform to target a region of interest in molecular imaging."
According to the news editors, the research concluded: "When we consider the biocompatibility of contrast agents in vivo, ATP@SPIONs are superior to polymeric surface-modified SPIONs."
For more information on this research see: Nonpolymeric Surface-Coated Iron Oxide Nanoparticles for In Vivo Molecular Imaging: Biodegradation, Biocompatibility, and Multiplatform. Journal of Nuclear Medicine, 2013;54(11):1974-1980. Journal of Nuclear Medicine can be contacted at: Soc Nuclear Medicine Inc, 1850 Samuel Morse Dr, Reston, VA 20190-5316, USA (see also Nanoparticles).
The news editors report that additional information may be obtained by contacting C.M. Lee, Chonnam National University, Sch Med, Dept. of Radiol, Kwangju, South Korea. Additional authors for this research include S.J. Cheong, E.M. Kim, S.T. Lim, Y.Y. Jeong, M.H. Sohn and H.J. Jeong.
Keywords for this news article include: Asia, Kwangju, South Korea, Nanotechnology, Molecular Imaging, Emerging Technologies
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