By a News Reporter-Staff News Editor at Drug Week -- New research on Drugs and Therapies is the subject of a report. According to news reporting from Bangalore, India, by NewsRx journalists, research stated, "The emergence of multidrug-resistant bacteria is a global threat for human society. There exist recorded data that silver was used as an antimicrobial agent by the ancient Greeks and Romans during the 8th century."
The news correspondents obtained a quote from the research from the Indian Institute of Science, "Silver nanoparticles (AgNPs) are of potential interest because of their effective antibacterial and antiviral activities, with minimal cytotoxic effects on the cells. However, very few reports have shown the usage of AgNPs for antibacterial therapy in vivo. In this study, we deciphered the importance of the chosen methods for synthesis and capping of AgNPs for their improved activity in vivo. The interaction of AgNPs with serum albumin has a significant effect on their antibacterial activity. It was observed that uncapped AgNPs exhibited no antibacterial activity in the presence of serum proteins, due to the interaction with bovine serum albumin (BSA), which was confirmed by UV-Vis spectroscopy. However, capped AgNPs [with citrate or poly(vinylpyrrolidone)] exhibited antibacterial properties due to minimized interactions with serum proteins. The damage in the bacterial membrane was assessed by flow cytometry, which also showed that only capped AgNPs exhibited antibacterial properties, even in the presence of BSA. In order to understand the in vivo relevance of the antibacterial activities of different AgNPs, a murine salmonellosis model was used. It was conclusively proved that AgNPs capped with citrate or PVP exhibited significant antibacterial activities in vivo against Salmonella infection compared to uncapped AgNPs."
According to the news reporters, the research concluded: "These results clearly demonstrate the importance of capping agents and the synthesis method for AgNPs in their use as antimicrobial agents for therapeutic purposes."
For more information on this research see: Interaction of silver nanoparticles with serum proteins affects their antimicrobial activity in vivo. Antimicrobial Agents and Chemotherapy, 2013;57(10):4945-55. (American Society for Microbiology - www.asm.org; Antimicrobial Agents and Chemotherapy - aac.asm.org)
Our news journalists report that additional information may be obtained by contacting D.P. Gnanadhas, Dept. of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India. Additional authors for this research include M. Ben Thomas, R. Thomas, A.M. Raichur and D. Chakravortty (see also Drugs and Therapies).
Keywords for this news article include: Asia, Antibacterial, Antibiotics, Antimicrobials, India, Peptides, Proteins, Bangalore, Amino Acids, Therapeutics, Drugs and Therapies.
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