By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Apoptosis have been published. According to news reporting originating from Shaanxi, People's Republic of China, by NewsRx correspondents, research stated, "Selenium chondroitin sulfate nanoparticles (SeCS) with a size range of 30-200 nm were obtained in our previous study. Meanwhile, the up-regulated expression of ATF2 mRNA and protein levels could be observed in the cartilage from Kashin-Beck disease (KBD) patients."
Our news editors obtained a quote from the research from Xi'an Jiao Tong University, "In this paper, we investigated the inhibition effect of SeCS on T-2-toxin-induced apoptosis of chondrocyte from KBD patients. Here, we found that when the chondrocytes were treated with T-2 toxin, the chondrocyte apoptosis performed in a concentration-dependent manner. The apoptosis of chondrocyte induced by T-2 toxin involved the increased levels of ATF2, JNK and p38 mRNAs and related protein expression. SeCS could partly block the T-2-toxin-induced chondrocyte apoptosis by decreasing the expression of ATF2, JNK and p38 mRNAs and p-JNK, p-38, ATF2 and p-ATF2 proteins. JNK and p38 pathways involved in the apoptosis of chondrocyte induced by T-2 toxin, and SeCS was efficient in the inhibition of chondrocyte apoptosis by T-2 toxin."
According to the news editors, the research concluded: "These results suggested that SeCS had a potential for further prevention and treatment for KBD as well as other selenium deficiency disease."
For more information on this research see: Down-regulation of ATF2 in the inhibition of T-2-toxin-induced chondrocyte apoptosis by selenium chondroitin sulfate nanoparticles. Journal of Nanoparticle Research, 2013;15(12):1-8. Journal of Nanoparticle Research can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Journal of Nanoparticle Research - www.springerlink.com/content/1388-0764/)
The news editors report that additional information may be obtained by contacting J. Han, Xi An Jiao Tong Univ, Coll Med, Fac Public HlthMinist EducMinist Hlth, Key Lab Environm & Gene Related DisKey Lab Trace, Xian 710061, Shaanxi, People's Republic of China (see also Apoptosis).
Keywords for this news article include: Asia, Shaanxi, Minerals, Selenium, Apoptosis, Chalcogens, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China
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