By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- A new study on Respiratory Tract is now available. According to news reporting from Raleigh, North Carolina, by NewsRx journalists, research stated, "This is a two-part paper describing inhaled nanoparticle (NP) transport and deposition in a model of a human respiratory tract (Part I) as well as NP-mass transfer across barriers into systemic regions (Part II). Specifically, combining high-resolution computer simulation results of inhaled NP deposition in the human airways (Part I) with a multi-compartmental model for NP-mass transfer (Part II) allows for the prediction of temporal NP accumulation in the blood and lymphatic systems as well as in organs."
The news correspondents obtained a quote from the research from North Carolina State University, "An understanding of nanoparticle transport and deposition in human respiratory airways is of great importance, as exposure to nanomaterial has been found to cause serious lung diseases, while the use of nanodrugs may have superior therapeutic effects. In Part I, the fluid-particle dynamics of a dilute NP suspension was simulated for the entire respiratory tract, assuming steady inhalation and planar airways. Thus, a realistic airway configuration was considered from nose/mouth to generation 3, and then an idealized triple-bifurcation unit was repeated in series and parallel to cover the remaining generations. Using the current model, the deposition of NPs in distinct regions of the lung, namely extrathoracic, bronchial, bronchiolar, and alveolar, was calculated. The region-specific NP-deposition results for the human lung model were used in Part II to determine the multicompartmental model parameters from experimental retention and clearance data in human lungs."
According to the news reporters, the research concluded: "The quantitative, experimentally validated results are useful in diverse fields, such as toxicology for exposure-risk analysis of ubiquitous nanomaterial as well as in pharmacology for nanodrug development and targeting."
For more information on this research see: Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics. Journal of Biomechanical Engineering-Transactions of the ASME, 2013;135(12):28-38. Journal of Biomechanical Engineering-Transactions of the ASME can be contacted at: Asme, Two Park Ave, New York, NY 10016-5990, USA (see also Respiratory Tract).
Our news journalists report that additional information may be obtained by contacting A.V. Kolanjiyil, North Carolina State University, Joint UNC NCSU, Dept. of Biomed Engn, Raleigh, NC 27695, United States.
Keywords for this news article include: Raleigh, Therapeutics, United States, North Carolina, Respiratory Tract, North and Central America
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