Iranian researchers from
Cells are naturally surrounded by extracellular matrix (ECM) that supports and guides cellular behavior and its vital functions, including migration, adhesion, proliferation and differentiation with the help of chemical and physical signals,
Therefore, the designing of internal pores and controlling external dimensions of the scaffold are the most important and effective parameters for assessing the performance of tissue engineering scaffolds used in the treatment of bone damage to guide cellular behavior in interaction with ECM.
In this research, nanocomposite scaffolds with controlled pore structure were produced through indirect three-dimensional printing method. The pores contained nanoparticles such as titanium dioxide and bioactive glass of micrometric and nanometric size. Growth kinetics of bone tissue was investigated on the product through in-vitro tests. To this end, the cast was made with three-dimensional structures and its surface was coated with paraffin.
Results of the research showed that the effective interface of particles and cells increase as nanoparticles is added to the polymeric bed due to the high tendency of nanoparticles to accumulate on the surface.
Moreover, nanoparticles affect cell adhesion, proliferation and differentiation by creating nanotopography and increasing coarseness and surface roughness.
Results of the research have been published in
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