By a News Reporter-Staff News Editor at Veterinary Week -- Researchers detail new data in Stem Cell Research. According to news reporting originating from Chunchon, South Korea, by VerticalNews correspondents, research stated, "Induced pluripotent stem cells (iPSCs) are thought to be highly beneficial in the field of regenerative medicine and are believed to overcome immunogenic barriers to cell transplantation. However, issues remain regarding their safety and efficiency for medical use."
Our news editors obtained a quote from the research from Kangwon National University, "Furthermore, some recent reports have suggested that iPSCs could be targeted by the autologous immune system. To promote practical applications of iPSCs, in depth research using appropriate animal models is needed and porcine species appear to provide an ideal model. Recent studies have focused on the generation of porcine iPSC cells, but no investigations of their immunological properties have been conducted to date. In the present study, we generated putative iPSCs from porcine somatic cells and measured major histocompatibility complex (MHC) expression on the iPSCs and their derivatives. Compact colonies that expressed pluripotent markers appeared 11 days after viral infection. Embryonic bodies (EB) were produced and differentiated into three germ layers in vitro. Karyotyping and swine leukocyte antigen (SLA) typing showed that the iPSCs were identical to parental somatic cells. Porcine iPSCs expressed only low levels of MHC class I and moderately increased levels on their differentiated derivatives, whereas MHC class II was rarely expressed. In the presence of interferon-gamma (IFN-gamma), the expression of MHC class I was elevated on differentiated iPSCs, and gradually decreased after withdrawal of the cytokine."
According to the news editors, the research concluded: "Our data suggest that porcine iPSCs could be useful for preclinical studies of the efficiency and viability of iPSCs, and for devising strategies to rescue transplanted cells from the autologous immune system."
For more information on this research see: Generation of porcine induced pluripotent stem cells and evaluation of their major histocompatibility complex protein expression in vitro. Veterinary Research Communications, 2013;37(4):293-301. Veterinary Research Communications can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Veterinary Research Communications - www.springerlink.com/content/0165-7380/)
The news editors report that additional information may be obtained by contacting K.M. Park, Kangwon Natl Univ, Coll Biomed Sci, Chunchon 200701, South Korea. Additional authors for this research include S.H. Cha, C. Ahn and H.M. Woo.
Keywords for this news article include: Asia, Biomedical Engineering, Biomedicine, Chunchon, Proteomics, South Korea, Bioengineering, Adult Stem Cells, Protein Expression, Stem Cell Research, Regenerative Medicine, Induced Pluripotent Stem Cells
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