By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Immunology have been published. According to news reporting from Singapore, Singapore, by NewsRx journalists, research stated, "Cancer-targeting gold/polyacrylamide (Au-PAm) hybrid nanogels were successfully synthesized via water/oil microemulsion polymerization followed by in situ reduction of gold and chemical modification with methotrexate (MTX). The Au nanoparticles range from similar to 3 to 7 nm and the loading in the hydrogel can be easily controlled."
The news correspondents obtained a quote from the research from Singapore National University, "Dynamic light scattering results showed that the hydrodynamic size distribution of these hybrid nanogels is similar to that of blank PAm nanogels (average diameter of similar to 30 nm), indicating that the Au nanoparticles were mostly incorporated into/onto the nanogels. MTX was used as both a targeting ligand and an anti-cancer drug for chemotherapy. The MTX-functionalized Au-PAm hybrid nanogels (Au-PAm-MTX) at a dosage of 0.5 mg/ml or higher can kill KB cells with high efficacy and suppress recovery of the cancer cells. On the other hand, the viability of macrophages showed no obvious decrease after incubation with Au-PAm-MTX, indicating that such materials are not likely to initiate immune responses in the physiological environment and their circulation life time will be prolonged."
According to the news reporters, the research concluded: "Hence, such hybrid nanogels can potentially enable safe and effective cancer chemotherapy via targeted co-delivery of cytotoxic Au NPs and MTX in a single carrier to KB cells while avoiding the macrophages."
For more information on this research see: Polyacrylamide hybrid nanogels for targeted cancer chemotherapy via co-delivery of gold nanoparticles and MTX. Journal of Colloid and Interface Science, 2013;412():46-55. Journal of Colloid and Interface Science can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Journal of Colloid and Interface Science - www.elsevier.com/wps/product/cws_home/622861)
Our news journalists report that additional information may be obtained by contacting S.J. Lu, Singapore National University, Dept. of Chem & Biomol Engn, Singapore 117576, Singapore. Additional authors for this research include K.G. Neoh, C. Huang, Z.L. Shi and E.T. Kang (see also Immunology).
Keywords for this news article include: Asia, Cancer, Nanogels, Oncology, Immunology, Macrophages, Nanotechnology, Gold Nanoparticles, Emerging Technologies, Mononuclear Phagocyte System
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