By a News Reporter-Staff News Editor at Stem Cell Week -- Current study results on Stem Cell Research have been published. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "The aim of this study was to obtain a better insight of how nano-fibrous scaffolds can affect human mesenchymal stem cells responses. Therefore, in this study, using electrospinning technique, poly(vinyl alcohol) (PVA) nano-fibers with two different patterns were prepared."
The news correspondents obtained a quote from the research from the University of Tehran, "In the first structure, PVA nano-fibers were oriented randomly and in the second structure, nano-fibers were electrospun in such a way that a special pattern was obtained. In order to enhance their stability, scaffolds were cross-linked using glutaraldehyde vapor. RGD immobilization was used to improve cell adhesion properties of the scaffolds. SEM micrographs demonstrated that the cell adhesion was effectively enhanced after RGD immobilization and higher cell densities were observed on RGD-modified scaffolds. Randomly oriented nano-fibers showed better cell adhesion compared to patterned structure. Patterned structure also revealed slightly lower cell viability compared to random nano-fibers."
According to the news reporters, the research concluded: "Finally, it was assumed that randomly oriented nano-fibers provide a more favorable surface for cells."
For more information on this research see: Response of Human Mesenchymal Stem Cells to Patterned and Randomly Oriented Poly(Vinyl Alcohol) Nano-fibrous Scaffolds Surface-Modified with Arg-Gly-Asp (RGD) Ligand. Applied Biochemistry and Biotechnology, 2013;171(6):1513-1524. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)
Our news journalists report that additional information may be obtained by contacting Y. Zamani, Univ Tehran Med Sci, Sch Dental, Dental Mat Department, Tehran, Iran. Additional authors for this research include M. Rabiee, M.A. Shokrgozar, S. Bonakdar and M. Tahriri (see also Stem Cell Research).
Keywords for this news article include: Iran, Asia, Tehran, Stem Cell Research, Mesenchymal Stem Cells
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