By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news originating from Kharagpur, India, by NewsRx correspondents, research stated, "A water soluble branched glucan (PS-I) was isolated from aqueous extract of the fruit bodies of an edible mushroom Macrolepiota dolichaula, having average molecular weight similar to 2.02 x 10(5) Da. The structure of this PS-I was determined using total hydrolysis, methylation analysis, Smith degradation, partial hydrolysis, and 1D/2D NMR experiments."
Our news journalists obtained a quote from the research from the Indian Institute of Technology, "Total hydrolysis and methylation analysis results showed the presence of (1 ? 3, 6)-, (1 ? 6)-, (1 ? 4)-, (1 ? 3)-linked and terminal beta-D-glucopyranosyl residues in a relative proportion of nearly 1:2:1:1:1. All the chemical and NMR results indicated that the PS-I was a branched glucan, and the repeating unit of this glucan consisted of a backbone chain of three (1 ? 6)linked-beta-D-glucopyranosyl residues where one of the backbone residues is branched at O-3 with (1 ? 3)-moiety which is further attached to another (1 ? 4)- residue and terminated with a non-reducing beta-D-glucopyranosyl residue."
According to the news editors, the research concluded: "The PS-I exhibited in vitro macrophage activation in RAW 264.7 cell line as well as splenocyte and thymocyte activation in mouse cell culture medium."
For more information on this research see: Structural characterization of an immunoenhancing glucan isolated from a mushroom Macrolepiota dolichaula. International Journal of Biological Macromolecules, 2013;61():89-96. International Journal of Biological Macromolecules can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Biological Macromolecules - www.elsevier.com/wps/product/cws_home/525446)
The news correspondents report that additional information may be obtained from S. Samanta, Indian Inst Technol, Dept. of Biotechnol, Kharagpur 721302, W Bengal, India. Additional authors for this research include A.K. Nandi, I.K. Sen, P.K. Maji, K.S.P. Devi, T.K. Maiti and S.S. Islam (see also Life Science Research).
Keywords for this news article include: Asia, India, Kharagpur, Life Science Research
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