By a News Reporter-Staff News Editor at Information Technology Newsweekly -- New research on Bioinformatics is the subject of a report. According to news reporting out of Philadelphia, Pennsylvania, by VerticalNews editors, research stated, "In order to more accurately predict an individual's health status, in clinical applications it is often important to perform analysis of high-dimensional gene expression data that varies with time. A major challenge in predicting from such temporal microarray data is that the number of biomarkers used as features is typically much larger than the number of labeled subjects."
Our news journalists obtained a quote from the research from Temple University, "One way to address this challenge is to perform feature selection as a preprocessing step and then apply a classification method on selected features. However, traditional feature selection methods cannot handle multivariate temporal data without applying techniques that flatten temporal data into a single matrix in advance. In this study, a feature selection filter that can directly select informative features from temporal gene expression data is proposed. In our approach, we measure the distance between multivariate temporal data from two subjects. Based on this distance, we define the objective function of temporal margin based feature selection to maximize each subject's temporal margin in its own relevant subspace."
According to the news editors, the research concluded: "The experimental results on synthetic and two real flu data sets provide evidence that our method outperforms the alternatives, which flatten the temporal data in advance."
For more information on this research see: Classifying temporal microarray data by selecting informative genes. Journal of Bioinformatics and Computational Biology, 2013;11(3):1341006. Journal of Bioinformatics and Computational Biology can be contacted at: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224. (World Scientific Publishing - www.worldscientific.com/; Journal of Bioinformatics and Computational Biology - www.worldscinet.com/jbcb/jbcb.shtml)
Our news journalists report that additional information may be obtained by contacting Q. Lou, Center for Data Analytics and Biomedical, Informatics Temple University, Philadelphia, Pennsylvania, United States.
Publisher contact information for the Journal of Bioinformatics and Computational Biology is: World Scientific Publishing Co. Pte. Ltd., 5 Toh Tuck Link, Singapore 596224.
Keywords for this news article include: Philadelphia, Pennsylvania, United States, Bioinformatics, North and Central America.
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