By a News Reporter-Staff News Editor at Drug Week -- New research on Phenylpropionates is the subject of a report. According to news originating from Belgrade, Serbia, by NewsRx correspondents, research stated, "The aim of our study was to evaluate the effect of designing ketoprofen-loaded nanosized spheres and combining them with solid silicon microneedles for enhanced and sustained percutaneous drug delivery. Ketoprofen-loaded nanoparticles (KET-NP) were designed by modified solvent displacement method, using poly (D, L-lactic acid) (PDLLA)."
Our news journalists obtained a quote from the research from the Institute of Technical Sciences, "All prepared nanoparticles were characterised with regard to their particle size distribution, morphology, surface properties, thermal behaviour, drug content, drug release and stability. In-vitro skin permeation studies were conducted on Franz-type diffusion cells using porcine skin treated with ImmuPatch silicon microneedles (Tyndall Nation Institute, Cork, Ireland). Key findings The study showed that uniform nanospheres were prepared with high encapsulation efficiency and retained stable for 2 months. After an initial burst release, the PDLLA nanoparticles were capable of sustaining and controlling ketoprofen release that followed Korsmeyer-Peppas kinetics. An enhanced flux of ketoprofen was observed in the skin treated with silicon microneedles over a prolonged period of time. Following application of silicon microneedle arrays, KET-NP were able to enhance ketoprofen flux and supply the porcine skin with drug over a prolonged (24 h) period of time."
According to the news editors, the research concluded: "Our findings indicate that the delivery strategy described here could be used for the further development of effective and painless administration systems for sustained percutaneous delivery of ketoprofen."
For more information on this research see: Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles. Journal of Pharmacy and Pharmacology, 2013;65(10):1451-1462. Journal of Pharmacy and Pharmacology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmacy and Pharmacology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)2042-7158)
The news correspondents report that additional information may be obtained from S.R. Vucen, Serbian Academy Arts & Sci, Inst Technical Sci, Belgrade, Serbia. Additional authors for this research include G. Vuleta, A.M. Crean, A.C. Moore, N. Ignjatovic and D. Uskokovic (see also Phenylpropionates).
Keywords for this news article include: Serbia, Europe, Belgrade, Ketoprofen, Nanoparticle, Nanotechnology, Phenylpropionates, Emerging Technologies
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