By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Intercellular Signaling Peptides and Proteins. According to news reporting out of Tehran, Iran, by NewsRx editors, research stated, "To exploit the therapeutic potential of growth factors in tissue regeneration, it is necessary to design a porous scaffold in order to concurrently accommodate cells and release angiogenic factors in a controlled manner. In an attempt to address these issues, we developed a nanocomposite scaffold based on silk/calcium phosphate/PLGA by freeze-drying and electrospinning in order to control the release of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF)."
Our news journalists obtained a quote from the research from Pasteur Institute, "The highly porous scaffold possessed appropriate chemical and physical structure as confirmed by FTIR, XRD, SEM, and Zeta potential analysis. Furthermore, the incorporation of PDGF and VEGF in the scaffold was confirmed using Raman spectroscopy while their bioactivity was maintained by 82% and 89% for up to 28 days, respectively. The release of PDGF was slower than VEGF as respected. Additionally, the scaffold could promote proliferation, alkaline phosphatase production and attachment of human osteoblast cells. Histological examination established new bone matrix formation with neovascularization in the angiogenic factors loaded scaffold after 10 weeks of implantation in rabbit model."
According to the news editors, the research concluded: "Finally, it was considered that the fabricated nanocomposite could be useful for bone tissue engineering applications."
For more information on this research see: Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold. International Journal of Pharmaceutics, 2013;454(1):216-225. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting M. Farokhi, Pasteur Inst Iran, Natl Cell Bank Iran, Tehran, Iran. Additional authors for this research include F. Mottaghitalab, J. Ai and M.A. Shokrgozar (see also Intercellular Signaling Peptides and Proteins).
Keywords for this news article include: Iran, Asia, Tehran, Anions, Blood Proteins, Protein Kinases, Phosphoric Acids, Calcium Compounds, Membrane Proteins, Calcium Phosphates, Angiogenic Proteins, Inorganic Chemicals, Phosphotransferases, Phosphorus Compounds, Growth Factor Receptors, Platelet-Derived Growth Factor, Receptor Protein-Tyrosine Kinases
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