By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Eye Diseases and Conditions have been published. According to news reporting out of Tokyo, Japan, by NewsRx editors, research stated, "To determine how evaluations of macular structures on spectral-domain optical coherence tomography compare with those of the optic disc and circumpapillary retinal nerve fiber layer (RNFL) in discriminating between highly myopic eyes with and without glaucoma. Retrospective, comparative study."
Our news journalists obtained a quote from the research from Institute for Statistics and Mathematics, "The appearances of ganglion cell layer and RNFL on Spectralis macular scans (Heidelberg Engineering) and optic disc on photographs were evaluated by 2 observers. The receiver operating characteristic regression was conducted for macular ganglion cell complex and circumpapillary RNFL measurements on RTVue-100 (Optovue). Ninety highly myopic eyes (-6.0 to -15.0 diopters; mean deviation [MD], -5.6 +/- 5.1 dB) and 91 non-highly myopic eyes (1.0 to -5.5 diopters; MD, -4.9 +/- 5.7 dB) were enrolled. In highly myopic eyes (< -6 diopters), the Cohen kappa for qualitative decisions by observers was 0.363 for photographs and 0.946 for Spectralis macular scans, and observers' evaluations of Spectralis macular scans were more accurate (94.5% and 94.5%, respectively; P< .0001) than their evaluations of photographs (71.4% and 80.2%, respectively). In the receiver operating characteristic regression analyses assessing the influences of age, sex, MD, and axial length, the better MD (P = .002 to .016) and longer axial length (P = .031 to .041) were associated significantly with diagnostic performances for all or some spectral-domain optical coherence tomography parameters. The receiver operating characteristic curves of average macular ganglion cell complex and circumpapillary RNFL thicknesses were comparable at low MD. In high myopes, observers' assessments of the spectral-domain optical coherence tomography macular scans may agree better and be more accurate than observers' optic disc assessments."
According to the news editors, the research concluded: "Glaucoma diagnostic performance of the macular ganglion cell complex may be less affected by axial length compared with that of circumpapillary RNFL."
For more information on this research see: Macular Imaging in Highly Myopic Eyes With and Without Glaucoma. American Journal of Ophthalmology, 2013;156(3):511-523. American Journal of Ophthalmology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; American Journal of Ophthalmology - www.elsevier.com/wps/product/cws_home/601028)
Our news journalists report that additional information may be obtained by contacting N. Nakano, Inst Stat Math, Tokyo, Japan. Additional authors for this research include M. Hangai, H. Noma, M. Nukada, S. Mori, S. Morooka, K. Takayama, Y. Kimura, H.O. Ikeda, T. Akagi and N. Yoshimura (see also Eye Diseases and Conditions).
Keywords for this news article include: Asia, Tokyo, Japan, Glaucoma, Imaging Technology, Clinical Trials and Studies, Eye Diseases and Conditions, Optical Coherence Tomography
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