By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on General Chemistry have been published. According to news reporting originating in Milton Keynes, United Kingdom, by NewsRx journalists, research stated, "Reflecting the increasing interest in combinatorial approaches, peptide phage display has seen an unprecedented expansion in a wide range of research areas. Its application to the discovery and analysis of metal binding peptides has opened up new research directions and largely contributed to the nanotechnology field."
The news reporters obtained a quote from the research from Open University, "The rationale behind the need to identify such peptides varies depending on the final aim of the research and its application. Therefore, the possibility to modify the selection technique according to the different requirements would allow for a more systematic approach to be adopted and would ultimately provide substantial benefits. Although the standard panning method can be virtually applied to any target, its use for the identification of metal binding peptides does not provide the characteristics and the flexibility required for an efficient and tailored selection. Here we report on the development of a new panning method that can contribute to a faster, versatile and more informative analysis. Through the use of rolling-circle amplification, polymerase reaction and wild type phage, we have converted the standard selection technique into a more dynamic process in which adjustments can be evaluated and made consistently with the need of the experiment. The successfulness of the improved method is demonstrated in a number of panning experiments with different inorganic targets. The modifications applied to each selection are described and comparisons between the results obtained are made in order to extensively assess and evaluate the impact of the new process. The importance of tailoring the screening method to the specific objectives of a study is also considered."
According to the news reporters, the research concluded: "New binder sequences for the materials included in the investigation are identified; their sequences and distinctive characteristics are reported and their ability to act as templates for the nucleation of inorganic material is demonstrated and discussed."
For more information on this research see: Enhancing in vitro selection techniques to assist the discovery, understanding and use of inorganic binding peptides. Dalton Transactions, 2013;42(28):10337-46. (Royal Society of Chemistry - www.rsc.org/; Dalton Transactions - pubs.rsc.org/en/journals/journalissues/dt)
Our news correspondents report that additional information may be obtained by contacting N. Frascione, Dept. of Life, Health and Chemical Sciences, Open University, Venables Building, Walton Hall, Milton Keynes, UK. Additional authors for this research include A. Codina-Barrios, A.R. Bassindale and P.G Taylor (see also General Chemistry).
Keywords for this news article include: Europe, Peptides, Proteins, Amino Acids, Milton Keynes, United Kingdom, General Chemistry.
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